ArticleDose-response : a publication of International Hormesis Society2014
Pre-conditioning with low-level laser (light) therapy: light before the storm.
Article in Dose-response : a publication of International Hormesis Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- A Role for Photobiomodulation in the Prevention of Myocardial Ischemic Reperfusion Injury: A Systematic Review and Potential Molecular Mechanisms.Scientific reports · 2017Pooled it
- The dark art of light measurement: accurate radiometry for low-level light therapy.Lasers in medical science · 2016Pooled it
- Photobiomodulation preconditioning for oral mucositis prevention and quality of life improvement in chemotherapy patients: a randomized clinical trial.BMC oral health · 2025Trial
- Orofacial evaluation of individuals with temporomandibular disorder after LED therapy associated or not of occlusal splint: a randomized double-blind controlled clinical study.Lasers in medical science · 2021Trial
- Photobiomodulation versus ischemic preconditioning for protection against exercise-induced muscle damage: protocol for a randomized controlled trial.Lasers in medical science · 2026Article
- A Dosimetric Reappraisal of the Photobiomodulation Literature Assessing Animal Safety and Phototoxicity Evidence for Photobiomodulation in Oncology: Phantom Dangers.Biomedicines · 2026Review
- LEDT and Idebenone treatment modulate autophagy and improve regenerative capacity in the dystrophic muscle through an AMPK-pathway.PloS one · 2024Article
- Analgesic Effect of Low-Level Laser Therapy before Heel Lance for Pain Management in Healthy Term Neonates: A Randomized Controlled Trial.Children (Basel, Switzerland) · 2023Article
- Photothermal Effects of High-Energy Photobiomodulation Therapies: An In Vitro Investigation.Biomedicines · 2023Article
- The different effects of low-level laser therapy before and after overinstrumentation on the expression of substance P and interleukin-10.The Saudi dental journal · 2023Article
- Photobiomodulation in 3D tissue engineering.Journal of biomedical optics · 2022Article
- Photobiomodulation therapy preconditioning modifies nitric oxide pathway and oxidative stress in human-induced pluripotent stem cell-derived ventricular cardiomyocytes treated with doxorubicin.Lasers in medical science · 2022Article
- Hypericin and Pheophorbide a Mediated Photodynamic Therapy Fighting MRSA Wound Infections: A Translational Study from In Vitro to In Vivo.Pharmaceutics · 2021Article
- Complementarity of Photo-Biomodulation, Surgical Treatment, and Antibiotherapy for Medication-Related Osteonecrosis of the Jaws (MRONJ).Medicina (Kaunas, Lithuania) · 2021Article
- Effects of prenatal photobiomodulation treatment on neonatal hypoxic ischemia in rat offspring.Theranostics · 2021Article
- Effect of Low-Level Laser Therapy and Sinensetin (Combination therapy) on Tumor Cells (Hela) and Normal Cells (CHO).Journal of lasers in medical sciences · 2021Article
- Photobiomodulation and Oral Mucositis: A Systematic Review.Dentistry journal · 2020Review
- Near infrared light amplifies endothelial progenitor cell accumulation after stroke.Conditioning medicine · 2019Article
- Photobiomodulation preconditioning prevents cognitive impairment in a neonatal rat model of hypoxia-ischemia.Journal of biophotonics · 2019Article
- Photobiomodulation for Global Cerebral Ischemia: Targeting Mitochondrial Dynamics and Functions.Molecular neurobiology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
Pre-conditioning by ischemia, hyperthermia, hypothermia, hyperbaric oxygen (and numerous other modalities) is a rapidly growing area of investigation that is used in pathological conditions where tissue damage may be expected. The damage caused by surgery, heart attack, or stroke can be mitigated by pre-treating the local or distant tissue with low levels of a stress-inducing stimulus, that can induce a protective response against subsequent major damage. Low-level laser (light) therapy (LLLT) has been used for nearly 50 years to enhance tissue healing and to relieve pain, inflammation and swelling. The photons are absorbed in cytochrome(c) oxidase (unit four in the mitochondrial respiratory chain), and this enzyme activation increases electron transport, respiration, oxygen consumption and ATP production. A complex signaling cascade is initiated leading to activation of transcription factors and up- and down-regulation of numerous genes. Recently it has become apparent that LLLT can also be effective if delivered to normal cells or tissue before the actual insult or trauma, in a pre-conditioning mode. Muscles are protected, nerves feel less pain, and LLLT can protect against a subsequent heart attack. These examples point the way to wider use of LLLT as a pre-conditioning modality to prevent pain and increase healing after surgical/medical procedures and possibly to increase athletic performance.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.