Evidence map›Paper›PMID 25552941›Full record

ArticleJournal of the Medical Library Association : JMLA2015

Building a gold standard to construct search filters: a case study with biomarkers for oral cancer.

John J Frazier, Corey D Stein, Eugene Tseytlin, Tanja Bekhuis

Open access · diamondAbstract read
In one paragraph

Article in Journal of the Medical Library Association : JMLA, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Roles for librarians in systematic reviews: a scoping review.Journal of the Medical Library Association : JMLA · 2018
    Article
  3. Keywords, discoverability, and impact.Journal of the Medical Library Association : JMLA · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

John J Frazierjjf60@pitt.edu , Fellow of the American Academy of Oral and Maxillofacial Pathology, Diplomate of the American Board of Oral and Maxillofacial Pathology, and National Library of Medicine Fellow; cds51@pitt.edu , Researcher; tseytlin@pitt.edu , Systems Developer; (Featured), tcb24@pitt.edu , Assistant Professor, Department of Biomedical Informatics and Department of Dental Public Health; School of Medicine and School of Dental Medicine, University of Pittsburgh, 5607 Baum Boulevard, Suite 514, Pittsburgh, PA 15206-3701.
Corey D Steinjjf60@pitt.edu , Fellow of the American Academy of Oral and Maxillofacial Pathology, Diplomate of the American Board of Oral and Maxillofacial Pathology, and National Library of Medicine Fellow; cds51@pitt.edu , Researcher; tseytlin@pitt.edu , Systems Developer; (Featured), tcb24@pitt.edu , Assistant Professor, Department of Biomedical Informatics and Department of Dental Public Health; School of Medicine and School of Dental Medicine, University of Pittsburgh, 5607 Baum Boulevard, Suite 514, Pittsburgh, PA 15206-3701.
Eugene Tseytlinjjf60@pitt.edu , Fellow of the American Academy of Oral and Maxillofacial Pathology, Diplomate of the American Board of Oral and Maxillofacial Pathology, and National Library of Medicine Fellow; cds51@pitt.edu , Researcher; tseytlin@pitt.edu , Systems Developer; (Featured), tcb24@pitt.edu , Assistant Professor, Department of Biomedical Informatics and Department of Dental Public Health; School of Medicine and School of Dental Medicine, University of Pittsburgh, 5607 Baum Boulevard, Suite 514, Pittsburgh, PA 15206-3701.
Tanja Bekhuisjjf60@pitt.edu , Fellow of the American Academy of Oral and Maxillofacial Pathology, Diplomate of the American Board of Oral and Maxillofacial Pathology, and National Library of Medicine Fellow; cds51@pitt.edu , Researcher; tseytlin@pitt.edu , Systems Developer; (Featured), tcb24@pitt.edu , Assistant Professor, Department of Biomedical Informatics and Department of Dental Public Health; School of Medicine and School of Dental Medicine, University of Pittsburgh, 5607 Baum Boulevard, Suite 514, Pittsburgh, PA 15206-3701.
Govt. Dental College & Hospital · IN

Funding

The internship in Biomedical Research, Informatics, and Computer Science (iBRIC): Biomedical Informatics and Data Science research experiences for students from Minority Serving InstitutionsT15LM007059 · NLM · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HARRY S HOCHHEISER · 1987 to 2026
$23.9M
Screening Nonrandomized Studies for Inclusion in Systematic Reviews of EvidenceR00LM010943 · NLM · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BEKHUIS, TANJA CATHARINA · 2012 to 2014
$639k
NLM NIH HHS 5R00LM010943NLM NIH HHS 5T15-LM007059NLM NIH HHS R00 LM010943NLM NIH HHS T15 LM007059
6 · The paper itself

Abstract

objectiveTo support clinical researchers, librarians and informationists may need search filters for particular tasks. Development of filters typically depends on a "gold standard" dataset. This paper describes generalizable methods for creating a gold standard to support future filter development and evaluation using oral squamous cell carcinoma (OSCC) as a case study. OSCC is the most common malignancy affecting the oral cavity. Investigation of biomarkers with potential prognostic utility is an active area of research in OSCC. The methods discussed here should be useful for designing quality search filters in similar domains.

methodsThe authors searched MEDLINE for prognostic studies of OSCC, developed annotation guidelines for screeners, ran three calibration trials before annotating the remaining body of citations, and measured inter-annotator agreement (IAA).

resultsWe retrieved 1,818 citations. After calibration, we screened the remaining citations (n = 1,767; 97.2%); IAA was substantial (kappa = 0.76). The dataset has 497 (27.3%) citations representing OSCC studies of potential prognostic biomarkers.

conclusionsThe gold standard dataset is likely to be high quality and useful for future development and evaluation of filters for OSCC studies of potential prognostic biomarkers. IMPLICATIONS: The methodology we used is generalizable to other domains requiring a reference standard to evaluate the performance of search filters. A gold standard is essential because the labels regarding relevance enable computation of diagnostic metrics, such as sensitivity and specificity. Librarians and informationists with data analysis skills could contribute to developing gold standard datasets and subsequent filters tuned for their patrons' domains of interest.

Indexed as

Medical Subject HeadingsBiomarkers, TumorDatabases, BibliographicHumansInformation DisseminationInformation Storage and RetrievalMEDLINEMouth NeoplasmsOrganizational Case StudiesPeriodicals as TopicReference StandardsBiomarkers, Tumor

Identifiers

PMID25552941
PMCPMC4279929
OpenAlexW2313395944

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.