ArticleInternational journal of medical sciences2015
Combination analysis in genetic polymorphisms of drug-metabolizing enzymes CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A5 in the Japanese population.
Article in International journal of medical sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 64 citations in OpenAlex.
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- Estimation of the benefit from pre-emptive genotyping based on the nationwide cohort data in South Korea.Clinical and translational science · 2024Review
- Impact of fresh grape juice on the pharmacokinetics of omeprazole: results of a food-drug interaction study.Frontiers in pharmacology · 2024Article
- CYP2C19 gene polymorphism in Ningxia.Pharmacological reports : PR · 2023Article
- Asia-Inclusive Clinical Research and Development Enabled by Translational Science and Quantitative Clinical Pharmacology: Toward a Culture That Challenges the Status Quo.Clinical pharmacology and therapeutics · 2023Article
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- Ethnicity-based classifications and medical genetics: One Health approaches from a Western Pacific perspective.Frontiers in genetics · 2022Review
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- Pharmacogenetics of tamoxifen therapy in Asian populations: from genetic polymorphism to clinical outcomes.European journal of clinical pharmacology · 2021Review
- Functional Characterization of 21 Rare AllelicJournal of personalized medicine · 2021Article
- Relationship between CYP3A5 Polymorphism and Tacrolimus Blood Concentration Changes in Allogeneic Hematopoietic Stem Cell Transplant Recipients during Continuous Infusion.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Effects of Different Processed Products ofEvidence-based complementary and alternative medicine : eCAM · 2020Article
- Randomized controlled study on the effects of triple therapy including vonoprazan or rabeprazole for the second-line treatment ofTherapeutic advances in gastroenterology · 2020Article
- Single nucleotide and structural variants of CYP2D6 gene in Kinh Vietnamese population.Medicine · 2019Article
- Influence ofPharmacogenomics and personalized medicine · 2019Article
- The Genetic Variation of CYP2D6 Gene in the Bosnian Population.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2018Article
- Polymorphic analysis of CYP2C9 gene in Vietnamese population.Molecular biology reports · 2018Article
- Genotype and Allele Frequency ofTurkish journal of pharmaceutical sciences · 2018Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Cytochrome P450 is the major enzyme involved in drug metabolism. CYP enzymes are responsible for the metabolism of most clinically used drugs. Individual variability in CYP activity is one important factor that contributes to drug therapy failure. We have developed a new straightforward TaqMan PCR genotyping assay to investigate the prevalence of the most common allelic variants of polymorphic CYP enzymes CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A5 in the Japanese population. Moreover, we focused on the combination of each genotype for clinical treatment. The genotype analysis identified a total of 139 out of 483 genotype combinations of five genes in the 1,003 Japanese subjects. According to our results, most of subjects seemed to require dose modification during clinical treatment. In the near future, modifications should be considered based on the individual patient genotype of each treatment.
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