ReviewCirculation research2015
Origin of cardiomyocytes in the adult heart.
Review in Circulation research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 86 citations in OpenAlex.
- Stratification of telomerase activity in cancer reveals associations with senescence and genomic instability.Computational and structural biotechnology journal · 2025Article
- A Machine Learning Approach to Gene Expression in Hypertrophic Cardiomyopathy.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Active Micro-Nano-Collaborative Bioelectronic Device for Advanced Electrophysiological Recording.Nano-micro letters · 2024Review
- A comprehensive review on 3D tissue models: Biofabrication technologies and preclinical applications.Biomaterials · 2024Review
- A review on regulation of DNA methylation during post-myocardial infarction.Frontiers in pharmacology · 2024Review
- Estradiol as the Trigger of Sirtuin-1-Dependent Cell Signaling with a Potential Utility in Anti-Aging Therapies.International journal of molecular sciences · 2023Review
- Engineering a conduction-consistent cardiac patch with graphene oxide modified butterfly wings and human pluripotent stem cell-derived cardiomyocytes.Bioengineering & translational medicine · 2023Article
- The Exciting Realities and Possibilities of iPS-Derived Cardiomyocytes.Bioengineering (Basel, Switzerland) · 2023Review
- Stem cell laden nano and micro collagen/PLGA bimodal fibrous patches for myocardial regeneration.Biomaterials research · 2022Article
- Targeting Epigenetic Regulation of Cardiomyocytes through Development for Therapeutic Cardiac Regeneration after Heart Failure.International journal of molecular sciences · 2022Review
- Effects of Treadmill Exercise on Mitochondrial DNA Damage and Cardiomyocyte Telomerase Activity in Aging Model Rats Based on Classical Apoptosis Signaling Pathway.BioMed research international · 2022Article
- Defining cardiac cell populations and relative cellular composition of the early fetal human heart.PloS one · 2022Article
- Extracellular vesicles in cardiac repair and regeneration: Beyond stem-cell-based approaches.Frontiers in cell and developmental biology · 2022Review
- Integrated analysis of telomerase enzymatic activity unravels an association with cancer stemness and proliferation.Nature communications · 2021Article
- Induction of Proteasome Subunit Low Molecular Weight Protein (LMP)-2 Is Required to Induce Active Remodeling in Adult Rat Ventricular Cardiomyocytes.Medical sciences (Basel, Switzerland) · 2020Article
- Computational modeling of cardiac growth and remodeling in pressure overloaded hearts-Linking microstructure to organ phenotype.Acta biomaterialia · 2020Review
- Human pluripotent stem cell-derived cardiomyocytes for studying energy metabolism.Biochimica et biophysica acta. Molecular cell research · 2020Review
- Gene therapy for refractory angina and cell therapy for heart failure: experience of a Brazilian research group.Gene therapy · 2020Review
- How to Stimulate Myocardial Regeneration in Adult Mammalian Heart: Existing Views and New Approaches.BioMed research international · 2020Review
- Restoring public trust in scientific research by reducing conflicts of interest.The Journal of clinical investigation · 2019Article
Corrections and comments
- Erratum issuedCorrection.2015
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
This review article discusses the mechanisms of cardiomyogenesis in the adult heart. They include the re-entry of cardiomyocytes into the cell cycle; dedifferentiation of pre-existing cardiomyocytes, which assume an immature replicating cell phenotype; transdifferentiation of hematopoietic stem cells into cardiomyocytes; and cardiomyocytes derived from activation and lineage specification of resident cardiac stem cells. The recognition of the origin of cardiomyocytes is of critical importance for the development of strategies capable of enhancing the growth response of the myocardium; in fact, cell therapy for the decompensated heart has to be based on the acquisition of this fundamental biological knowledge.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.