ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2015
Genetic knockdown of estrogen receptor-alpha in the subfornical organ augments ANG II-induced hypertension in female mice.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Central Interaction of 2-Methoxyestradiol and Lipoxygenase in AngII-Hypertension.Hypertension (Dallas, Tex. : 1979) · 2025Article
- The interaction of BDNF with estrogen in the development of hypertension and obesity, particularly during menopause.Frontiers in endocrinology · 2024Review
- The adverse role of endocrine disrupting chemicals in the reproductive system.Frontiers in endocrinology · 2023Review
- Loss of the Protective Effect of Estrogen Contributes to Maternal Gestational Hypertension-Induced Hypertensive Response Sensitization Elicited by Postweaning High-Fat Diet in Female Offspring.Journal of the American Heart Association · 2022Article
- Central CYP1B1 (Cytochrome P450 1B1)-Estradiol Metabolite 2-Methoxyestradiol Protects From Hypertension and Neuroinflammation in Female Mice.Hypertension (Dallas, Tex. : 1979) · 2020Article
- Roles of oestradiol receptor alpha and beta against hypertension and brain mitochondrial dysfunction under intermittent hypoxia in female rats.Acta physiologica (Oxford, England) · 2019Article
- Sex differences in the central and peripheral manifestations of ischemia-induced heart failure in rats.American journal of physiology. Heart and circulatory physiology · 2019Article
- The proinflammatory cytokine tumor necrosis factor-α excites subfornical organ neurons.Journal of neurophysiology · 2017Article
- Divergent effects of ERα and ERβ on fluid intake by female rats are not dependent on concomitant changes in AT1R expression or body weight.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Estrogen Receptor α Is Required for Maintaining Baseline Renin Expression.Hypertension (Dallas, Tex. : 1979) · 2016Article
- Estrogen Replacement Reduces Oxidative Stress in the Rostral Ventrolateral Medulla of Ovariectomized Rats.Oxidative medicine and cellular longevity · 2016Article
- Recent advances in central cardiovascular control: sex, ROS, gas and inflammation.F1000Research · 2016Review
- Sex, the brain and hypertension: brain oestrogen receptors and high blood pressure risk factors.Clinical science (London, England : 1979) · 2016Review
- Genetic knockdown of brain-derived neurotrophic factor in the nervous system attenuates angiotensin II-induced hypertension in mice.Journal of the renin-angiotensin-aldosterone system : JRAASArticle
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The present study tested the hypotheses that 1) ERα in the brain plays a key role in the estrogen-protective effects against ANG II-induced hypertension, and 2) that the subfornical organ (SFO) is a key site where ERα mediates these protective actions. In this study, a "floxed" ERα transgenic mouse line (ERα(flox)) was used to create models in which ERα was knocked down in the brain or just in the SFO. Female mice with ERα ablated in the nervous system (Nestin-ERα(-) mice) showed greater increases in blood pressure (BP) in response to ANG II. Furthermore, females with ERα knockdown specifically in the SFO [SFO adenovirus-Cre (Ad-Cre) injected ERα(flox) mice] also showed an enhanced pressor response to ANG II. Immunohistochemical (IHC), RT-PCR, and Western blot analyses revealed a marked reduction in the expression of ERα in nervous tissues and, in particular, in the SFO. These changes were not present in peripheral tissues in Nestin-ERα(-) mice or Ad-Cre-injected ERα(flox) mice. mRNA expression of components of the renin-angiotensin system in the lamina terminalis were upregulated in Nestin-ERα(-) mice. Moreover, ganglionic blockade on day 7 after ANG II infusions resulted in a greater reduction of BP in Nestin-ERα(-) mice or SFO Ad-Cre-injected mice, suggesting that knockdown of ERα in the nervous system or the SFO alone augments central ANG II-induced increase in sympathetic tone. The results indicate that interfering with the action of estrogen on SFO ERα is sufficient to abolish the protective effects of estrogen against ANG II-induced hypertension.
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