ArticleHuman molecular genetics2015
Prenatal exposure to maternal smoking and offspring DNA methylation across the lifecourse: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC).
Article in Human molecular genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 217 papers, 13 of them syntheses that pooled it.
What it found
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Who cites it
217 citing papers in PubMed, 13 syntheses or guidelines pooled it.
- The Role of Genetics in Stroke Risk and Outcome: A Review of Current Evidence.Brain and behavior · 2025Pooled it
- Maternal hypertensive disorders during pregnancy and their link to childhood asthma: a systematic review and meta-analysis.Frontiers in pediatrics · 2025Pooled it
- Prenatal tobacco use and the risk of mood disorders in offspring: a systematic review and meta-analysis.Social psychiatry and psychiatric epidemiology · 2020Pooled it
- Pooled it
- A meta-analysis of two high-risk prospective cohort studies reveals autism-specific transcriptional changes to chromatin, autoimmune, and environmental response genes in umbilical cord blood.Molecular autism · 2019Pooled it
- Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults.EBioMedicine · 2018Pooled it
- Environmental Epigenetic Changes, as Risk Factors for the Development of Diseases in Children: A Systematic Review.Annals of global health · 2018Pooled it
- Maternal alcohol consumption and offspring DNA methylation: findings from six general population-based birth cohorts.Epigenomics · 2018Pooled it
- An epigenome-wide association study meta-analysis of educational attainment.Molecular psychiatry · 2017Pooled it
- Breastfeeding effects on DNA methylation in the offspring: A systematic literature review.PloS one · 2017Pooled it
- Epigenome-Wide Meta-Analysis of Methylation in Children Related to Prenatal NO2 Air Pollution Exposure.Environmental health perspectives · 2017Pooled it
- DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis.American journal of human genetics · 2016Pooled it
- An epigenome-wide association meta-analysis of prenatal maternal stress in neonates: A model approach for replication.Epigenetics · 2016Pooled it
- Development and Validation of a Novel Placental DNA Methylation Biomarker of Maternal Smoking during Pregnancy in the ECHO Program.Environmental health perspectives · 2024Trial
- Improvements in lung function following vitamin C supplementation to pregnant smokers are associated with buccal DNA methylation at 5 years of age.Clinical epigenetics · 2024Trial
- Epigenetic signatures of starting and stopping smoking.EBioMedicine · 2018Trial
- Vitamin C Prevents Offspring DNA Methylation Changes Associated with Maternal Smoking in Pregnancy.American journal of respiratory and critical care medicine · 2017Trial
- Reduced mouse allergen is associated with epigenetic changes in regulatory genes, but not mouse sensitization, in asthmatic children.Environmental research · 2017Trial
- Pubertal development in healthy children is mirrored by DNA methylation patterns in peripheral blood.Scientific reports · 2016Trial
- Effect of prenatal DHA supplementation on the infant epigenome: results from a randomized controlled trial.Clinical epigenetics · 2016Trial
157 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Maternal smoking during pregnancy has been found to influence newborn DNA methylation in genes involved in fundamental developmental processes. It is pertinent to understand the degree to which the offspring methylome is sensitive to the intensity and duration of prenatal smoking. An investigation of the persistence of offspring methylation associated with maternal smoking and the relative roles of the intrauterine and postnatal environment is also warranted. In the Avon Longitudinal Study of Parents and Children, we investigated associations between prenatal exposure to maternal smoking and offspring DNA methylation at multiple time points in approximately 800 mother-offspring pairs. In cord blood, methylation at 15 CpG sites in seven gene regions (AHRR, MYO1G, GFI1, CYP1A1, CNTNAP2, KLF13 and ATP9A) was associated with maternal smoking, and a dose-dependent response was observed in relation to smoking duration and intensity. Longitudinal analysis of blood DNA methylation in serial samples at birth, age 7 and 17 years demonstrated that some CpG sites showed reversibility of methylation (GFI1, KLF13 and ATP9A), whereas others showed persistently perturbed patterns (AHRR, MYO1G, CYP1A1 and CNTNAP2). Of those showing persistence, we explored the effect of postnatal smoke exposure and found that the major contribution to altered methylation was attributed to a critical window of in utero exposure. A comparison of paternal and maternal smoking and offspring methylation showed consistently stronger maternal associations, providing further evidence for causal intrauterine mechanisms. These findings emphasize the sensitivity of the methylome to maternal smoking during early development and the long-term impact of such exposure.
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