ArticleJournal of neurophysiology2015
Spatiotemporal dynamics of optogenetically induced and spontaneous seizure transitions in primary generalized epilepsy.
Article in Journal of neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
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- Chronic alteration of CabioRxiv : the preprint server for biology · 2025Article
- Animal Models of Epilepsy: A Phenotype-oriented Review.Aging and disease · 2022Review
- The impact of a closed-loop thalamocortical model on the spatiotemporal dynamics of cortical and thalamic traveling waves.Scientific reports · 2021Article
- Chronic loss of inhibition in piriform cortex following brief, daily optogenetic stimulation.Cell reports · 2021Article
- Perampanel reduces paroxysmal depolarizing shift and inhibitory synaptic input in excitatory neurons to inhibit epileptic network oscillations.British journal of pharmacology · 2020Article
- An Optogenetic Kindling Model of Neocortical Epilepsy.Scientific reports · 2019Article
- Novel Optogenetic Approaches in Epilepsy Research.Frontiers in neuroscience · 2019Review
- Light-induced regulation of ligand-gated channel activity.British journal of pharmacology · 2018Review
- Microbial Proteins as Novel Industrial Biotechnology Hosts to Treat Epilepsy.Molecular neurobiology · 2017Review
- Optogenetic study of networks in epilepsy.Journal of neuroscience research · 2017Review
- A new description of epileptic seizures based on dynamic analysis of a thalamocortical model.Scientific reports · 2017Article
- Review: Human Intracortical Recording and Neural Decoding for Brain-Computer Interfaces.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2017Review
- Control of in vivo ictogenesis via endogenous synaptic pathways.Scientific reports · 2017Article
- Seizing Control: From Current Treatments to Optogenetic Interventions in Epilepsy.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2017Article
- Seizure Detection and Network Dynamics of Generalized Convulsive Seizures: Towards Rational Designing of Closed-Loop Neuromodulation.Neuroscience journal · 2017Article
- Dynamics of sensorimotor cortex activation during absence and myoclonic seizures in a mouse model of juvenile myoclonic epilepsy.Epilepsia · 2016Article
- Predicting seizures from local field potentials recorded via intracortical microelectrode arrays.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2016Article
- Sulforhodamine 101, a widely used astrocyte marker, can induce cortical seizure-like activity at concentrations commonly used.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Transitions into primary generalized epileptic seizures occur abruptly and synchronously across the brain. Their potential triggers remain unknown. We used optogenetics to causally test the hypothesis that rhythmic population bursting of excitatory neurons in a local neocortical region can rapidly trigger absence seizures. Most previous studies have been purely correlational, and it remains unclear whether epileptiform events induced by rhythmic stimulation (e.g., sensory/electrical) mimic actual spontaneous seizures, especially regarding their spatiotemporal dynamics. In this study, we used a novel combination of intracortical optogenetic stimulation and microelectrode array recordings in freely moving WAG/Rij rats, a model of absence epilepsy with a cortical focus in the somatosensory cortex (SI). We report three main findings: 1) Brief rhythmic bursting, evoked by optical stimulation of neocortical excitatory neurons at frequencies around 10 Hz, induced seizures consisting of self-sustained spike-wave discharges (SWDs) for about 10% of stimulation trials. The probability of inducing seizures was frequency-dependent, reaching a maximum at 10 Hz. 2) Local field potential power before stimulation and response amplitudes during stimulation both predicted seizure induction, demonstrating a modulatory effect of brain states and neural excitation levels. 3) Evoked responses during stimulation propagated as cortical waves, likely reaching the cortical focus, which in turn generated self-sustained SWDs after stimulation was terminated. Importantly, SWDs during induced and spontaneous seizures propagated with the same spatiotemporal dynamics. Our findings demonstrate that local rhythmic bursting of excitatory neurons in neocortex at particular frequencies, under susceptible ongoing brain states, is sufficient to trigger primary generalized seizures with stereotypical spatiotemporal dynamics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.