Evidence map›Paper›PMID 25552592›Full record

ArticleCirculation. Cardiovascular genetics2015

Variants for HDL-C, LDL-C, and triglycerides identified from admixture mapping and fine-mapping analysis in African American families.

Priya B Shetty, Hua Tang, Tao Feng, Bamidele Tayo, Alanna C Morrison, Sharon L R Kardia, Craig L Hanis, Donna K Arnett, Steven C Hunt, Eric Boerwinkle and 5 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Cardiovascular genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

  1. Trial
  2. Article
  3. Strategies for the Genomic Analysis of Admixed Populations.Annual review of biomedical data science · 2023
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. International journal of clinical and experimental pathology · 2017
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 1 country.

Priya B ShettyFrom the Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH (P.B.S., T.F., X.Z.); Department of Genetics, Stanford University School of Medicine, Stanford, CA (H.T.); Department of Public Health Sciences, Loyola University of Chicago Stritch School of Medicine, Maywood, IL (B.T., R.S.C.); Division of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas Health Science Center at Houston School of Public Health (A.C.M., C.L.H., E.B.); Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor (S.L.R.K.); Department of Epidemiology, University of Alabama at Birmingham School of Public Health (D.K.A.); Cardiovascular Genetics Division, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City (S.C.H.); Division of Biostatistics, Washington University in St. Louis School of Medicine, St. Louis, MO (D.C. Rao); and Department of Epidemiology and Biostatistics, University of California, San Francisco (N.R.).
Hua TangFrom the Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH (P.B.S., T.F., X.Z.); Department of Genetics, Stanford University School of Medicine, Stanford, CA (H.T.); Department of Public Health Sciences, Loyola University of Chicago Stritch School of Medicine, Maywood, IL (B.T., R.S.C.); Division of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas Health Science Center at Houston School of Public Health (A.C.M., C.L.H., E.B.); Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor (S.L.R.K.); Department of Epidemiology, University of Alabama at Birmingham School of Public Health (D.K.A.); Cardiovascular Genetics Division, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City (S.C.H.); Division of Biostatistics, Washington University in St. Louis School of Medicine, St. Louis, MO (D.C. Rao); and Department of Epidemiology and Biostatistics, University of California, San Francisco (N.R.).
Tao FengFrom the Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH (P.B.S., T.F., X.Z.); Department of Genetics, Stanford University School of Medicine, Stanford, CA (H.T.); Department of Public Health Sciences, Loyola University of Chicago Stritch School of Medicine, Maywood, IL (B.T., R.S.C.); Division of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas Health Science Center at Houston School of Public Health (A.C.M., C.L.H., E.B.); Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor (S.L.R.K.); Department of Epidemiology, University of Alabama at Birmingham School of Public Health (D.K.A.); Cardiovascular Genetics Division, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City (S.C.H.); Division of Biostatistics, Washington University in St. Louis School of Medicine, St. Louis, MO (D.C. Rao); and Department of Epidemiology and Biostatistics, University of California, San Francisco (N.R.).
Bamidele TayoFrom the Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH (P.B.S., T.F., X.Z.); Department of Genetics, Stanford University School of Medicine, Stanford, CA (H.T.); Department of Public Health Sciences, Loyola University of Chicago Stritch School of Medicine, Maywood, IL (B.T., R.S.C.); Division of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas Health Science Center at Houston School of Public Health (A.C.M., C.L.H., E.B.); Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor (S.L.R.K.); Department of Epidemiology, University of Alabama at Birmingham School of Public Health (D.K.A.); Cardiovascular Genetics Division, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City (S.C.H.); Division of Biostatistics, Washington University in St. Louis School of Medicine, St. Louis, MO (D.C. Rao); and Department of Epidemiology and Biostatistics, University of California, San Francisco (N.R.).
Alanna C MorrisonFrom the Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH (P.B.S., T.F., X.Z.); Department of Genetics, Stanford University School of Medicine, Stanford, CA (H.T.); Department of Public Health Sciences, Loyola University of Chicago Stritch School of Medicine, Maywood, IL (B.T., R.S.C.); Division of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas Health Science Center at Houston School of Public Health (A.C.M., C.L.H., E.B.); Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor (S.L.R.K.); Department of Epidemiology, University of Alabama at Birmingham School of Public Health (D.K.A.); Cardiovascular Genetics Division, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City (S.C.H.); Division of Biostatistics, Washington University in St. Louis School of Medicine, St. Louis, MO (D.C. Rao); and Department of Epidemiology and Biostatistics, University of California, San Francisco (N.R.).
Sharon L R KardiaFrom the Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH (P.B.S., T.F., X.Z.); Department of Genetics, Stanford University School of Medicine, Stanford, CA (H.T.); Department of Public Health Sciences, Loyola University of Chicago Stritch School of Medicine, Maywood, IL (B.T., R.S.C.); Division of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas Health Science Center at Houston School of Public Health (A.C.M., C.L.H., E.B.); Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor (S.L.R.K.); Department of Epidemiology, University of Alabama at Birmingham School of Public Health (D.K.A.); Cardiovascular Genetics Division, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City (S.C.H.); Division of Biostatistics, Washington University in St. Louis School of Medicine, St. Louis, MO (D.C. Rao); and Department of Epidemiology and Biostatistics, University of California, San Francisco (N.R.).
Craig L HanisFrom the Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH (P.B.S., T.F., X.Z.); Department of Genetics, Stanford University School of Medicine, Stanford, CA (H.T.); Department of Public Health Sciences, Loyola University of Chicago Stritch School of Medicine, Maywood, IL (B.T., R.S.C.); Division of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas Health Science Center at Houston School of Public Health (A.C.M., C.L.H., E.B.); Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor (S.L.R.K.); Department of Epidemiology, University of Alabama at Birmingham School of Public Health (D.K.A.); Cardiovascular Genetics Division, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City (S.C.H.); Division of Biostatistics, Washington University in St. Louis School of Medicine, St. Louis, MO (D.C. Rao); and Department of Epidemiology and Biostatistics, University of California, San Francisco (N.R.).
Donna K ArnettFrom the Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH (P.B.S., T.F., X.Z.); Department of Genetics, Stanford University School of Medicine, Stanford, CA (H.T.); Department of Public Health Sciences, Loyola University of Chicago Stritch School of Medicine, Maywood, IL (B.T., R.S.C.); Division of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas Health Science Center at Houston School of Public Health (A.C.M., C.L.H., E.B.); Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor (S.L.R.K.); Department of Epidemiology, University of Alabama at Birmingham School of Public Health (D.K.A.); Cardiovascular Genetics Division, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City (S.C.H.); Division of Biostatistics, Washington University in St. Louis School of Medicine, St. Louis, MO (D.C. Rao); and Department of Epidemiology and Biostatistics, University of California, San Francisco (N.R.).
Steven C HuntFrom the Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH (P.B.S., T.F., X.Z.); Department of Genetics, Stanford University School of Medicine, Stanford, CA (H.T.); Department of Public Health Sciences, Loyola University of Chicago Stritch School of Medicine, Maywood, IL (B.T., R.S.C.); Division of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas Health Science Center at Houston School of Public Health (A.C.M., C.L.H., E.B.); Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor (S.L.R.K.); Department of Epidemiology, University of Alabama at Birmingham School of Public Health (D.K.A.); Cardiovascular Genetics Division, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City (S.C.H.); Division of Biostatistics, Washington University in St. Louis School of Medicine, St. Louis, MO (D.C. Rao); and Department of Epidemiology and Biostatistics, University of California, San Francisco (N.R.).
Eric BoerwinkleFrom the Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH (P.B.S., T.F., X.Z.); Department of Genetics, Stanford University School of Medicine, Stanford, CA (H.T.); Department of Public Health Sciences, Loyola University of Chicago Stritch School of Medicine, Maywood, IL (B.T., R.S.C.); Division of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas Health Science Center at Houston School of Public Health (A.C.M., C.L.H., E.B.); Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor (S.L.R.K.); Department of Epidemiology, University of Alabama at Birmingham School of Public Health (D.K.A.); Cardiovascular Genetics Division, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City (S.C.H.); Division of Biostatistics, Washington University in St. Louis School of Medicine, St. Louis, MO (D.C. Rao); and Department of Epidemiology and Biostatistics, University of California, San Francisco (N.R.).
Candidate Gene Association Resource (CARe) Consortium
Dabeeru C RaoFrom the Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH (P.B.S., T.F., X.Z.); Department of Genetics, Stanford University School of Medicine, Stanford, CA (H.T.); Department of Public Health Sciences, Loyola University of Chicago Stritch School of Medicine, Maywood, IL (B.T., R.S.C.); Division of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas Health Science Center at Houston School of Public Health (A.C.M., C.L.H., E.B.); Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor (S.L.R.K.); Department of Epidemiology, University of Alabama at Birmingham School of Public Health (D.K.A.); Cardiovascular Genetics Division, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City (S.C.H.); Division of Biostatistics, Washington University in St. Louis School of Medicine, St. Louis, MO (D.C. Rao); and Department of Epidemiology and Biostatistics, University of California, San Francisco (N.R.).
Richard S CooperFrom the Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH (P.B.S., T.F., X.Z.); Department of Genetics, Stanford University School of Medicine, Stanford, CA (H.T.); Department of Public Health Sciences, Loyola University of Chicago Stritch School of Medicine, Maywood, IL (B.T., R.S.C.); Division of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas Health Science Center at Houston School of Public Health (A.C.M., C.L.H., E.B.); Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor (S.L.R.K.); Department of Epidemiology, University of Alabama at Birmingham School of Public Health (D.K.A.); Cardiovascular Genetics Division, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City (S.C.H.); Division of Biostatistics, Washington University in St. Louis School of Medicine, St. Louis, MO (D.C. Rao); and Department of Epidemiology and Biostatistics, University of California, San Francisco (N.R.).
Neil RischFrom the Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH (P.B.S., T.F., X.Z.); Department of Genetics, Stanford University School of Medicine, Stanford, CA (H.T.); Department of Public Health Sciences, Loyola University of Chicago Stritch School of Medicine, Maywood, IL (B.T., R.S.C.); Division of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas Health Science Center at Houston School of Public Health (A.C.M., C.L.H., E.B.); Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor (S.L.R.K.); Department of Epidemiology, University of Alabama at Birmingham School of Public Health (D.K.A.); Cardiovascular Genetics Division, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City (S.C.H.); Division of Biostatistics, Washington University in St. Louis School of Medicine, St. Louis, MO (D.C. Rao); and Department of Epidemiology and Biostatistics, University of California, San Francisco (N.R.).
Xiaofeng ZhuFrom the Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH (P.B.S., T.F., X.Z.); Department of Genetics, Stanford University School of Medicine, Stanford, CA (H.T.); Department of Public Health Sciences, Loyola University of Chicago Stritch School of Medicine, Maywood, IL (B.T., R.S.C.); Division of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas Health Science Center at Houston School of Public Health (A.C.M., C.L.H., E.B.); Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor (S.L.R.K.); Department of Epidemiology, University of Alabama at Birmingham School of Public Health (D.K.A.); Cardiovascular Genetics Division, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City (S.C.H.); Division of Biostatistics, Washington University in St. Louis School of Medicine, St. Louis, MO (D.C. Rao); and Department of Epidemiology and Biostatistics, University of California, San Francisco (N.R.). Xiaofeng.Zhu@case.edu.
Loyola University Chicago · USThe University of Texas Health Science Center at Houston · USUniversity of Michigan–Ann Arbor · USUniversity of Alabama at Birmingham · USUniversity of Chicago · USUniversity of Utah · USWashington University in St. Louis · US

Funding

HYPERGEN: GENETICS OF LEFT VENTRICULAR HYPERTROPHYR01HL055673 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ARNETT, DONNA K · 1996 to 2016
$18.1M
X-LINKED EXTENSION OF THE REVISED HASEMAN-ELSTON ALGORITHM FOR LINKAGE ANALYSISP41RR003655 · NCRR · LOUISIANA STATE UNIV HSC NEW ORLEANS · PI ELSTON, ROBERT C. · 1987 to 2011
$11.5M
BIOMETRIC-GENETIC ANALYSIS OF CARDIOVASCULAR DISEASET32HL007567 · NHLBI · LOUISIANA STATE UNIV HSC NEW ORLEANS · PI ZHU, XIAOFENG · 1985 to 2021
$6.0M
CHS Events Follow-up StudyU01HL080295 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2005 to 2008
$4.6M
JACKSON HEART STUDY--EXAM CENTERN01HC095171 · HC · UNIVERSITY OF MISSISSIPPI MEDICAL CENTER · PI JONES, DANIEL W · 1999 to 2001
$4.6M
Statistical methods for analyzing high-throughput genotype dataR01HG003054 · NHGRI · LOYOLA UNIVERSITY CHICAGO · PI ZHU, XIAOFENG · 2005 to 2017
$3.6M
FAMILIAL AGGREGATION OF OBSTRUCTIVE SLEEP APNEAR01HL046380 · NHLBI · UNIVERSITY HOSPITALS OF CLEVELAND · PI REDLINE, SUSAN S · 1990 to 2005
$3.5M
Fine Mapping of Hypertension Genes Detected by Admixture Mapping in the FBPPR01HL086718 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI ZHU, XIAOFENG · 2007 to 2011
$3.3M
VASCULAR CALCIUM--AN EPIDEMIOLOGIC STUDYR01HL048050 · NHLBI · UNIVERSITY OF IOWA · PI MAHONEY, LARRY T · 1992 to 2004
$3.0M
Genetic Architecture of Complex Traits in Admixed PopulationsR01GM073059 · NIGMS · STANFORD UNIVERSITY · PI TANG, HUA · 2005 to 2016
$2.4M
Cigarette Smoke and Susceptibility to Influenza InfectionR01HL095163 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JASPERS, ILONA, NOAH, TERRY L · 2009 to 2013
$2.0M
Role of EIIIA fibronectin in pulmonary fibrosisR01HL085083 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WHITE, ERIC S · 2007 to 2011
$1.9M
NCRR NIH HHS P41 RR003655NCRR NIH HHS RR03655NHGRI NIH HHS R01 HG003054NHLBI NIH HHS HL007567-29NHLBI NIH HHS HL086718NHLBI NIH HHS N01 HC005187NHLBI NIH HHS N01 HC015103NHLBI NIH HHS N01 HC035129NHLBI NIH HHS N01 HC045133NHLBI NIH HHS N01 HC045134NHLBI NIH HHS N01 HC045204NHLBI NIH HHS N01 HC045205NHLBI NIH HHS N01 HC048047NHLBI NIH HHS N01 HC048048NHLBI NIH HHS N01 HC048049NHLBI NIH HHS N01 HC048050NHLBI NIH HHS N01 HC055015NHLBI NIH HHS N01 HC055016NHLBI NIH HHS N01 HC055018NHLBI NIH HHS N01 HC055019NHLBI NIH HHS N01 HC055020NHLBI NIH HHS N01 HC055021NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC065226NHLBI NIH HHS N01 HC075150NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085084NHLBI NIH HHS N01 HC085085NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095095NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N01 HC095170NHLBI NIH HHS N01 HC095171NHLBI NIH HHS N01 HC095172NHLBI NIH HHS R01 HL046380NHLBI NIH HHS R01 HL055673NHLBI NIH HHS R01 HL086718NHLBI NIH HHS T32 HL007567NHLBI NIH HHS U01 HL080295NIGMS NIH HHS R01 GM073059
6 · The paper itself

Abstract

backgroundAdmixture mapping of lipids was followed-up by family-based association analysis to identify variants for cardiovascular disease in African Americans. METHODS AND

resultsThe present study conducted admixture mapping analysis for total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides. The analysis was performed in 1905 unrelated African American subjects from the National Heart, Lung and Blood Institute's Family Blood Pressure Program (FBPP). Regions showing admixture evidence were followed-up with family-based association analysis in 3556 African American subjects from the FBPP. The admixture mapping and family-based association analyses were adjusted for age, age(2), sex, body mass index, and genome-wide mean ancestry to minimize the confounding caused by population stratification. Regions that were suggestive of local ancestry association evidence were found on chromosomes 7 (low-density lipoprotein cholesterol), 8 (high-density lipoprotein cholesterol), 14 (triglycerides), and 19 (total cholesterol and triglycerides). In the fine-mapping analysis, 52 939 single-nucleotide polymorphisms (SNPs) were tested and 11 SNPs (8 independent SNPs) showed nominal significant association with high-density lipoprotein cholesterol (2 SNPs), low-density lipoprotein cholesterol (4 SNPs), and triglycerides (5 SNPs). The family data were used in the fine-mapping to identify SNPs that showed novel associations with lipids and regions, including genes with known associations for cardiovascular disease.

conclusionsThis study identified regions on chromosomes 7, 8, 14, and 19 and 11 SNPs from the fine-mapping analysis that were associated with high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides for further studies of cardiovascular disease in African Americans.

Indexed as

Chromosome MappingPolymorphism, Single NucleotideAdultAgedAged, 80 and overBlack or African AmericanCardiovascular DiseasesCholesterol, HDLCholesterol, LDLChromosomes, HumanFamilyFemaleHumansMaleMiddle AgedTriglyceridesCholesterol, HDLCholesterol, LDLTriglyceridesadmixture mappingAfrican Americansassociation studiesgeneticslipids

Identifiers

PMID25552592
PMCPMC4378661
OpenAlexW2040296009

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