ArticleSocial cognitive and affective neuroscience2015
Impaired acquisition of classically conditioned fear-potentiated startle reflexes in humans with focal bilateral basolateral amygdala damage.
Article in Social cognitive and affective neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analytic evidence for downregulation of the amygdala during working memory maintenance.Human brain mapping · 2022Pooled it
- The human amygdala in threat learning and extinction.Science advances · 2026Article
- The unique face of comorbid anxiety and depression: Increased frontal, insula and cingulate cortex response during Pavlovian fear-conditioning.Journal of affective disorders · 2024Article
- Article
- Distributed neural representations of conditioned threat in the human brain.Nature communications · 2024Article
- The unique face of anxious depression: Increased sustained threat circuitry response during fear acquisition.bioRxiv : the preprint server for biology · 2023Article
- Fear-potentiated startle reveals diminished threat extinction in pathological anxiety.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2023Article
- Pattern analysis of neuroimaging data reveals novel insights on threat learning and extinction in humans.Neuroscience and biobehavioral reviews · 2022Review
- Ionic signalling mechanisms involved in neurokinin-3 receptor-mediated augmentation of fear-potentiated startle response in the basolateral amygdala.The Journal of physiology · 2022Article
- Temporally and anatomically specific contributions of the human amygdala to threat and safety learning.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Temporal dynamics of affect in the brain: Evidence from human imaging and animal models.Neuroscience and biobehavioral reviews · 2022Review
- The effect of stress and reward on encoding future fear memories.Behavioural brain research · 2022Review
- Mental imagery can generate and regulate acquired differential fear conditioned reactivity.Scientific reports · 2022Article
- Robust BOLD Responses to Faces But Not to Conditioned Threat: Challenging the Amygdala's Reputation in Human Fear and Extinction Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Bilateral amygdala damage linked to impaired ability to predict others' fear but preserved moral judgements about causing others fear.Proceedings. Biological sciences · 2021Article
- Organic cation transporter 3 and the dopamine transporter differentially regulate catecholamine uptake in the basolateral amygdala and nucleus accumbens.The European journal of neuroscience · 2020Article
- Investigating the efficacy of the reminder-extinction procedure to disrupt contextual threat memories in humans using immersive Virtual Reality.Scientific reports · 2020Article
- Sex Differences in Internalizing Symptoms and Amygdala Functional Connectivity in Neurotypical Youth.Developmental cognitive neuroscience · 2020Article
- Candidate Biomarkers of Suicide Crisis Syndrome: What to Test Next? A Concept Paper.The international journal of neuropsychopharmacology · 2020Review
- Patients with dorsolateral prefrontal cortex lesions are capable of discriminatory threat learning but appear impaired in cognitive regulation of subjective fear.Social cognitive and affective neuroscience · 2019Article
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Based on studies in rodents, the basolateral amygdala (BLA) is considered a key site for experience-dependent neural plasticity underlying the acquisition of conditioned fear responses. In humans, very few studies exist of subjects with selective amygdala lesions and those studies have only implicated the amygdala more broadly leaving the role of amygdala sub-regions underexplored. We tested a rare sample of subjects (N = 4) with unprecedented focal bilateral BLA lesions due to a genetic condition called Urbach-Wiethe disease. In a classical delay fear conditioning experiment, these subjects showed impaired acquisition of conditioned fear relative to a group of matched control subjects (N = 10) as measured by fear-potentiation of the defensive eye-blink startle reflex. After the experiment, the BLA-damaged cases showed normal declarative memory of the conditioned association. Our findings provide new evidence that the human BLA is essential to drive fast classically conditioned defensive reflexes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.