ArticleAmerican journal of hypertension2015
Association of Uric Acid With Vascular Stiffness in the Framingham Heart Study.
Article in American journal of hypertension, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.
- Weight loss for overweight and obese individuals with gout: a systematic review of longitudinal studies.Annals of the rheumatic diseases · 2017Pooled it
- Vascular Function and Uric Acid-Lowering in Stage 3 CKD.Journal of the American Society of Nephrology : JASN · 2017Trial
- Cf-PWV but not cr-PWV or cd-PWV is associated with cardiovascular mortality in patients with chronic kidney disease.BMC nephrology · 2025Article
- The role of uric acid in the risk of hypertension developed from prehypertension: a five-year Chinese urban cohort study.Archives of public health = Archives belges de sante publique · 2024Article
- Clinical effects of a selective urate reabsorption inhibitor dotinurad in patients with hyperuricemia and treated hypertension: a multicenter, prospective, exploratory study (DIANA).European journal of medical research · 2023Article
- Mutual effect of homocysteine and uric acid on arterial stiffness and cardiovascular risk in the context of predictive, preventive, and personalized medicine.The EPMA journal · 2022Article
- Association between serum uric acid and arterial stiffness in a large-aged 40-70 years old population.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Inflammaging and Vascular Function in Metabolic Syndrome: The Role of Hyperuricemia.Medicina (Kaunas, Lithuania) · 2022Article
- Uric acid and arterial stiffness in children and adolescents: Role of insulin resistance and blood pressure.Frontiers in cardiovascular medicine · 2022Article
- Prevalence and modifiable risk factors of degenerative valvular heart disease among elderly population in southern China.Journal of geriatric cardiology : JGC · 2021Article
- Plasma uric acid is related to large arterial stiffness but not to other hemodynamic variables: a study in 606 normotensive and never-medicated hypertensive subjects.BMC cardiovascular disorders · 2021Article
- Association between the uric acid and hypertension in community-based Chinese population: stratified analysis based on body mass index and age.Journal of thrombosis and thrombolysis · 2021Article
- Mediation of Arterial Stiffness for Hyperuricemia-Related Decline of Cardiac Systolic Function in Healthy Men.Circulation reports · 2021Article
- Selected matrix metalloproteinases activity and hypertension-mediated organ damage in relation to uric acid serum level.Cardiology journal · 2021Article
- The Effect of Body Adiposity and Alcohol Consumption on Serum Uric Acid: A Quantile Regression Analysis Based on the China National Health Survey.Frontiers in nutrition · 2021Article
- Aortic Stiffness: Epidemiology, Risk Factors, and Relevant Biomarkers.Frontiers in cardiovascular medicine · 2021Review
- Sugar-sweetened beverage consumption and risk of hyperuricemia: a longitudinal analysis of the Health Workers Cohort Study participants in Mexico.The American journal of clinical nutrition · 2020Article
- Plasma levels of matrix metalloproteinase-9 are elevated in individuals with hypertensive crisis.BMC cardiovascular disorders · 2020Article
- Preoperative uric acid predicts in-hospital death in patients with acute type a aortic dissection.Journal of cardiothoracic surgery · 2020Article
- Systemic Arterial Stiffness in New Diagnosed Idiopathic Pulmonary Arterial Hypertension Patients.Vascular health and risk management · 2020Article
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6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundUric acid is associated with increased risk of cardiovascular disease and arterial stiffness in patients with hypertension or stroke. It remains unknown if uric acid is associated with arterial stiffness in the general population.
methodsWe analyzed the association between serum uric acid levels and measures of arterial stiffness such as carotid-femoral pulse wave velocity (CF PWV), carotid-radial pulse wave velocity (CR PWV) and augmentation index (AI) in 4,140 participants from the Generation 3 Framingham cohort using linear regression.
resultsMean (SD) age was 40.0 (8.8) years and mean (SD) serum uric acid levels were 5.3 (1.5) mg/dl. Mean (SD) CF PWV was 7.0 (1.4) m/s. Individuals in the highest quartile of uric acid were more likely to be male, have a higher prevalence of hypertension, higher BMI, fasting glucose and insulin, and lower estimated glomerular filtration rate (eGFR). Multivariate adjusted means of CF PWV were 6.90, 6.94, 7.06, and 7.15 m/s for uric acid quartile 1, 2, 3, and 4 respectively. In unadjusted analysis each 1mg/dl increase in uric acid was associated with higher CF-PWV (β = 0.27; 95% CI = 0.25, 0.29; P < 0.0001). This was attenuated but remained significant after adjusting for age, sex, smoking, hypertension, BMI, fasting glucose, insulin, animal protein intake, and eGFR (β= 0.06; 95% CI = 0.02, 0.09; P < 0.0007). There was no association between serum uric acid levels and AI upon adjustment for cardiovascular risk factors.
conclusionsSerum uric acid levels are significantly associated with CF PWV and CR PWV in a younger Caucasian population.
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