Evidence map›Paper›PMID 25552491›Full record

ArticleCirculation. Cardiovascular imaging2015

Extracellular volume fraction is more closely associated with altered regional left ventricular velocities than left ventricular ejection fraction in nonischemic cardiomyopathy.

Jeremy Collins, Cort Sommerville, Patrick Magrath, Bruce Spottiswoode, Benjamin H Freed, Keith H Benzuly, Robert Gordon, Himabindu Vidula, Dan C Lee, Clyde Yancy and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Cardiovascular imaging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Effects of Transendocardial CD34Stem cells translational medicine · 2017
    Trial
  2. Article
  3. Article
  4. Left ventricular ejection fraction and myocardial fibrosis in sudden cardiac death.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Association between left ventricular mechanics and diffuse myocardial fibrosis in patients with repaired Tetralogy of Fallot: a cross-sectional study.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2017
    Article
  10. Extra-cellular expansion in the normal, non-infarcted myocardium is associated with worsening of regional myocardial function after acute myocardial infarction.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2017
    Article
  11. Review
  12. Review
  13. Article
  14. Heart deformation analysis: measuring regional myocardial velocity with MR imaging.The international journal of cardiovascular imaging · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 2 countries.

Jeremy CollinsFrom the Departments of Radiology (J. Collins, C.S., J. Carr, M.M.) and Biomedical Engineering (P.M., M.M.) and Division of Cardiology, Department of Medicine (B.H.F., K.H.B., R.G., H.V., D.C.L., C.Y.), Feinberg School of Medicine, Northwestern University, Chicago, IL; and Siemens Medical Solutions USA, Chicago, IL (B.S.).
Cort SommervilleFrom the Departments of Radiology (J. Collins, C.S., J. Carr, M.M.) and Biomedical Engineering (P.M., M.M.) and Division of Cardiology, Department of Medicine (B.H.F., K.H.B., R.G., H.V., D.C.L., C.Y.), Feinberg School of Medicine, Northwestern University, Chicago, IL; and Siemens Medical Solutions USA, Chicago, IL (B.S.).
Patrick MagrathFrom the Departments of Radiology (J. Collins, C.S., J. Carr, M.M.) and Biomedical Engineering (P.M., M.M.) and Division of Cardiology, Department of Medicine (B.H.F., K.H.B., R.G., H.V., D.C.L., C.Y.), Feinberg School of Medicine, Northwestern University, Chicago, IL; and Siemens Medical Solutions USA, Chicago, IL (B.S.).
Bruce SpottiswoodeFrom the Departments of Radiology (J. Collins, C.S., J. Carr, M.M.) and Biomedical Engineering (P.M., M.M.) and Division of Cardiology, Department of Medicine (B.H.F., K.H.B., R.G., H.V., D.C.L., C.Y.), Feinberg School of Medicine, Northwestern University, Chicago, IL; and Siemens Medical Solutions USA, Chicago, IL (B.S.).
Benjamin H FreedFrom the Departments of Radiology (J. Collins, C.S., J. Carr, M.M.) and Biomedical Engineering (P.M., M.M.) and Division of Cardiology, Department of Medicine (B.H.F., K.H.B., R.G., H.V., D.C.L., C.Y.), Feinberg School of Medicine, Northwestern University, Chicago, IL; and Siemens Medical Solutions USA, Chicago, IL (B.S.).
Keith H BenzulyFrom the Departments of Radiology (J. Collins, C.S., J. Carr, M.M.) and Biomedical Engineering (P.M., M.M.) and Division of Cardiology, Department of Medicine (B.H.F., K.H.B., R.G., H.V., D.C.L., C.Y.), Feinberg School of Medicine, Northwestern University, Chicago, IL; and Siemens Medical Solutions USA, Chicago, IL (B.S.).
Robert GordonFrom the Departments of Radiology (J. Collins, C.S., J. Carr, M.M.) and Biomedical Engineering (P.M., M.M.) and Division of Cardiology, Department of Medicine (B.H.F., K.H.B., R.G., H.V., D.C.L., C.Y.), Feinberg School of Medicine, Northwestern University, Chicago, IL; and Siemens Medical Solutions USA, Chicago, IL (B.S.).
Himabindu VidulaFrom the Departments of Radiology (J. Collins, C.S., J. Carr, M.M.) and Biomedical Engineering (P.M., M.M.) and Division of Cardiology, Department of Medicine (B.H.F., K.H.B., R.G., H.V., D.C.L., C.Y.), Feinberg School of Medicine, Northwestern University, Chicago, IL; and Siemens Medical Solutions USA, Chicago, IL (B.S.).
Dan C LeeFrom the Departments of Radiology (J. Collins, C.S., J. Carr, M.M.) and Biomedical Engineering (P.M., M.M.) and Division of Cardiology, Department of Medicine (B.H.F., K.H.B., R.G., H.V., D.C.L., C.Y.), Feinberg School of Medicine, Northwestern University, Chicago, IL; and Siemens Medical Solutions USA, Chicago, IL (B.S.).
Clyde YancyFrom the Departments of Radiology (J. Collins, C.S., J. Carr, M.M.) and Biomedical Engineering (P.M., M.M.) and Division of Cardiology, Department of Medicine (B.H.F., K.H.B., R.G., H.V., D.C.L., C.Y.), Feinberg School of Medicine, Northwestern University, Chicago, IL; and Siemens Medical Solutions USA, Chicago, IL (B.S.).
James CarrFrom the Departments of Radiology (J. Collins, C.S., J. Carr, M.M.) and Biomedical Engineering (P.M., M.M.) and Division of Cardiology, Department of Medicine (B.H.F., K.H.B., R.G., H.V., D.C.L., C.Y.), Feinberg School of Medicine, Northwestern University, Chicago, IL; and Siemens Medical Solutions USA, Chicago, IL (B.S.).
Michael MarklFrom the Departments of Radiology (J. Collins, C.S., J. Carr, M.M.) and Biomedical Engineering (P.M., M.M.) and Division of Cardiology, Department of Medicine (B.H.F., K.H.B., R.G., H.V., D.C.L., C.Y.), Feinberg School of Medicine, Northwestern University, Chicago, IL; and Siemens Medical Solutions USA, Chicago, IL (B.S.). michael.markl@northwestern.edu.
Northwestern University · US

Funding

Comprehensive Cardiac Structure-Function Analysis in Heart TransplantationR01HL117888 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CARR, JAMES, MARKL, MICHAEL · 2014 to 2025
$6.4M
NHLBI NIH HHS 1R01 HL117888NHLBI NIH HHS R01 HL117888
6 · The paper itself

Abstract

backgroundNonischemic cardiomyopathy is a common cause of left ventricular (LV) dysfunction and myocardial fibrosis. The purpose of this study was to noninvasively evaluate changes in segmental LV extracellular volume (ECV) fraction, LV velocities, myocardial scar, and wall motion in nonischemic cardiomyopathy patients. METHODS AND

resultsCardiac MRI including pre- and postcontrast myocardial T1 mapping and velocity quantification (tissue phase mapping) of the LV (basal, midventricular, and apical short axis) was applied in 31 patients with nonischemic cardiomyopathy (50±18 years). Analysis based on the 16-segment American Heart Association model was used to evaluate the segmental distribution of ECV, peak systolic and diastolic myocardial velocities, scar determined by late gadolinium enhancement, and wall motion abnormalities. LV segments with scar or impaired wall motion were significantly associated with elevated ECV (rs =0.26; P<0.001) and reduced peak systolic radial velocities (r=-0.43; P<0.001). Regional myocardial velocities and ECV were similar for patients with reduced (n=12; ECV=0.28±0.06) and preserved left ventricular ejection fraction (n=19; ECV=0.30±0.09). Patients with preserved left ventricular ejection fraction showed significant relationships between increasing ECV and reduced systolic (r=-0.19; r=-0.30) and diastolic (r=0.34; r=0.26) radial and long-axis peak velocities (P<0.001). Even after excluding myocardial segments with late gadolinium enhancement, significant relationships between ECV and segmental LV velocities were maintained indicating the potential of elevated ECV to identify regional diffuse fibrosis not visible by late gadolinium enhancement, which was associated with impaired regional LV function.

conclusionsRegionally elevated ECV negatively affected myocardial velocities. The association of elevated regional ECV with reduced myocardial velocities independent of left ventricular ejection fraction suggests a structure-function relationship between altered ECV and segmental myocardial function in nonischemic cardiomyopathy.

Indexed as

Myocardial ContractionStroke VolumeVentricular Function, LeftAdultAgedCardiomyopathiesCicatrixContrast MediaFemaleFibrosisHumansMagnetic Resonance Imaging, CineMaleMiddle AgedMyocardiumPredictive Value of TestsContrast Mediacardiomyopathiesfibrosismagnetic resonance imagingventricular function, left

Identifiers

PMID25552491
PMCPMC4283574
OpenAlexW2313332942

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.