Evidence map›Paper›PMID 25552429›Full record

ArticleThe international journal of neuropsychopharmacology2014

Antidepressant effects of abscisic acid mediated by the downregulation of corticotrophin-releasing hormone gene expression in rats.

Cong-Cong Qi, Zhi Zhang, Hui Fang, Ji Liu, Nan Zhou, Jin-Fang Ge, Fang-Han Chen, Cheng-Bin Xiang, Jiang-Ning Zhou

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The international journal of neuropsychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 49 citations in OpenAlex.

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  12. The bioactive potential of phytohormones: A review.Biotechnology reports (Amsterdam, Netherlands) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Cong-Cong QiCAS Key Laboratory of Brain Function and Diseases, Schol of Life Science, University of Science and Technology of China, Anhui, China (Drs Qi, Zhang, Fang, Liu, Ge, Chen, and J-N Zhou); Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China (Dr N Zhou); Plant Molecular Biology Laboratory, School of Life Science, University of Science and Technology of China, Anhui, China (Dr Xiang).
Zhi ZhangCAS Key Laboratory of Brain Function and Diseases, Schol of Life Science, University of Science and Technology of China, Anhui, China (Drs Qi, Zhang, Fang, Liu, Ge, Chen, and J-N Zhou); Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China (Dr N Zhou); Plant Molecular Biology Laboratory, School of Life Science, University of Science and Technology of China, Anhui, China (Dr Xiang).
Hui FangCAS Key Laboratory of Brain Function and Diseases, Schol of Life Science, University of Science and Technology of China, Anhui, China (Drs Qi, Zhang, Fang, Liu, Ge, Chen, and J-N Zhou); Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China (Dr N Zhou); Plant Molecular Biology Laboratory, School of Life Science, University of Science and Technology of China, Anhui, China (Dr Xiang).
Ji LiuCAS Key Laboratory of Brain Function and Diseases, Schol of Life Science, University of Science and Technology of China, Anhui, China (Drs Qi, Zhang, Fang, Liu, Ge, Chen, and J-N Zhou); Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China (Dr N Zhou); Plant Molecular Biology Laboratory, School of Life Science, University of Science and Technology of China, Anhui, China (Dr Xiang).
Nan ZhouCAS Key Laboratory of Brain Function and Diseases, Schol of Life Science, University of Science and Technology of China, Anhui, China (Drs Qi, Zhang, Fang, Liu, Ge, Chen, and J-N Zhou); Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China (Dr N Zhou); Plant Molecular Biology Laboratory, School of Life Science, University of Science and Technology of China, Anhui, China (Dr Xiang).
Jin-Fang GeCAS Key Laboratory of Brain Function and Diseases, Schol of Life Science, University of Science and Technology of China, Anhui, China (Drs Qi, Zhang, Fang, Liu, Ge, Chen, and J-N Zhou); Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China (Dr N Zhou); Plant Molecular Biology Laboratory, School of Life Science, University of Science and Technology of China, Anhui, China (Dr Xiang).
Fang-Han ChenCAS Key Laboratory of Brain Function and Diseases, Schol of Life Science, University of Science and Technology of China, Anhui, China (Drs Qi, Zhang, Fang, Liu, Ge, Chen, and J-N Zhou); Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China (Dr N Zhou); Plant Molecular Biology Laboratory, School of Life Science, University of Science and Technology of China, Anhui, China (Dr Xiang).
Cheng-Bin XiangCAS Key Laboratory of Brain Function and Diseases, Schol of Life Science, University of Science and Technology of China, Anhui, China (Drs Qi, Zhang, Fang, Liu, Ge, Chen, and J-N Zhou); Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China (Dr N Zhou); Plant Molecular Biology Laboratory, School of Life Science, University of Science and Technology of China, Anhui, China (Dr Xiang).
Jiang-Ning ZhouCAS Key Laboratory of Brain Function and Diseases, Schol of Life Science, University of Science and Technology of China, Anhui, China (Drs Qi, Zhang, Fang, Liu, Ge, Chen, and J-N Zhou); Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China (Dr N Zhou); Plant Molecular Biology Laboratory, School of Life Science, University of Science and Technology of China, Anhui, China (Dr Xiang). jnzhou@ustc.edu.cn.
Huashan Hospital · CNFudan University · CNUniversity of Science and Technology of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCorticotrophin-releasing hormone (CRH) is considered to be the central driving force of the hypothalamic-pituitary-adrenal axis, which plays a key role in the stress response and depression. Clinical reports have suggested that excess retinoic acid (RA) is associated with depression. Abscisic acid (ABA) and RA are direct derivatives of carotenoids and share a similar molecular structure. Here, we proposed that ABA also plays a role in the regulation of CRH activity sharing with the RA signaling pathway.

methods[3H]-ABA radioimmunoassay demonstrated that the hypothalamus of rats shows the highest concentration of ABA compared with the cortex and the hippocampus under basal conditions.

resultsUnder acute stress, ABA concentrations increased in the serum, but decreased in the hypothalamus and were accompanied by increased corticosterone in the serum and c-fos expression in the hypothalamus. Moreover, chronic ABA administration increased sucrose intake and decreased the mRNA expression of CRH and retinoic acid receptor alpha (RARα) in the hypothalamus of rats. Furthermore, ABA improved the symptom of chronic unpredictable mild stress in model rats, as indicated by increased sucrose intake, increased swimming in the forced swim test, and reduced mRNA expression of CRH and RARα in the rat hypothalamus. In vitro, CRH expression decreased after ABA treatment across different neural cells. In BE(2)-C cells, ABA inhibited a series of retinoid receptor expression, including RARα, a receptor that could facilitate CRH expression directly.

conclusionsThese results suggest that ABA may play a role in the pathogenesis of depression by downregulating CRH mRNA expression shared with the RA signaling pathway.

Indexed as

Abscisic AcidAnimalsAntidepressive AgentsCerebral CortexCorticosteroneCorticotropin-Releasing HormoneDepressive DisorderDietary SucroseDisease Models, AnimalDown-RegulationGene ExpressionHippocampusHypothalamusMaleProto-Oncogene Proteins c-fosRandom AllocationAbscisic AcidAntidepressive AgentsCorticosteroneCorticotropin-Releasing HormoneDietary SucroseProto-Oncogene Proteins c-fosRara protein, ratReceptors, Retinoic AcidRetinoic Acid Receptor alphaRNA, Messengerabscisic acidcorticotrophin-releasing hormonedepressionretinoic acid receptor alphastress response

Identifiers

PMID25552429
PMCPMC4360223
OpenAlexW2129336808

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.