ArticleThe Journal of infectious diseases2015
Alveolar Macrophages Isolated Directly From Human Cytomegalovirus (HCMV)-Seropositive Individuals Are Sites of HCMV Reactivation In Vivo.
Article in The Journal of infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 55 citations in OpenAlex.
- UL45 of Human Cytomegalovirus Promotes Macrophage Survival and Modulates RIPK3-Associated Cell Death.Viruses · 2026Article
- Sensing the storm: how inflammatory signalling drives reactivation of the human cytomegalovirus major immediate-early promoter.The Journal of general virology · 2026Review
- Breaking barriers: how cytomegaloviruses manipulate myeloid cells to invade tissues.EMBO reports · 2026Review
- Alveolar Macrophages in Viral Respiratory Infections: Sentinels and Saboteurs of Lung Defense.International journal of molecular sciences · 2025Review
- CMV Infection Risk Factors and Viral Dynamics After Valganciclovir Prophylaxis: 10 Years of Experience in Lung Transplant Recipients.Microorganisms · 2024Article
- CMV Retinitis in the Context of SARS-CoV-2 Infection: A Case Study and Comprehensive Review of Viral Interactions.Pathogens (Basel, Switzerland) · 2024Review
- Breast milk induces the differentiation of monocytes into macrophages, promoting human cytomegalovirus infection.Journal of virology · 2024Article
- Molecular characterization of human cytomegalovirus infection with single-cell transcriptomics.Nature microbiology · 2023Article
- Human Cytomegalovirus Infection of Epithelial Cells Increases SARS-CoV-2 Superinfection by Upregulating the ACE2 Receptor.The Journal of infectious diseases · 2023Article
- Does reactivation of cytomegalovirus contribute to severe COVID-19 disease?Immunity & ageing : I & A · 2021Article
- Human cytomegalovirus major immediate early transcripts arise predominantly from the canonical major immediate early promoter in reactivating progenitor-derived dendritic cells.The Journal of general virology · 2020Article
- Cell signaling and cytomegalovirus reactivation: what do Src family kinases have to do with it?Biochemical Society transactions · 2020Review
- Alveolar Macrophage Immunometabolism and Lung Function Impairment in Smoking and Chronic Obstructive Pulmonary Disease.American journal of respiratory and critical care medicine · 2020Article
- Adaptive NKG2C+ natural killer cells are related to exacerbations and nutritional abnormalities in COPD patients.Respiratory research · 2020Article
- Interferon-Responsive Genes Are Targeted during the Establishment of Human Cytomegalovirus Latency.mBio · 2019Article
- Advances in the treatment of cytomegalovirus.British medical bulletin · 2019Article
- Generation, maintenance and tissue distribution of T cell responses to human cytomegalovirus in lytic and latent infection.Medical microbiology and immunology · 2019Review
- HCMV latency: what regulates the regulators?Medical microbiology and immunology · 2019Review
- STING induces early IFN-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus.Nature communications · 2019Article
- Challenges and Clinical Implications of the Diagnosis of Cytomegalovirus Lung Infection in Children.Current infectious disease reports · 2019Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Human cytomegalovirus (HCMV) causes significant morbidity in the immunocompromised host. Following primary infection, the virus establishes latent infection in progenitor cells of the myeloid lineage. These cells exhibit limited viral gene transcription and no evidence of de novo virion production. It is well recognized that differentiation of latently infected myeloid progenitor cells to dendritic or macrophage-like cells permits viral reactivation in vitro. This has been used to support the concept that viral reactivation in HCMV carriers routinely occurs from such terminally differentiated myeloid cells in vivo. However, to date this has not been shown for in vivo-differentiated macrophages. This study is the first to demonstrate that alveolar macrophages from HCMV carriers express immediate early lytic genes and produce infectious virus. This supports the view, until now based on in vitro data, that terminally differentiated myeloid cells in vivo are sites of HCMV reactivation and potential centers of viral dissemination in latently infected individuals with no evidence of virus disease or dissemination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.