ArticlePloS one2014
Poor clinical outcomes among pneumonia patients with depressive disorder.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed.
- All-cause and cause-specific mortality in people with depression: a large-scale systematic review and meta-analysis of relative risk and aggravating or attenuating factors, including antidepressant treatment.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025Article
- Major psychiatric comorbidity among the critically ill: a multi-centred cohort study in Queensland.BMC psychiatry · 2025Article
- Comparison of severe hyponatremia in patients with and without psychiatric diseases: A single-center retrospective study.PCN reports : psychiatry and clinical neurosciences · 2023Article
- Major depressive disorders increase the susceptibility to self-reported infections in two German cohort studies.Social psychiatry and psychiatric epidemiology · 2023Article
- Post-COVID-19 Depressive Symptoms: Epidemiology, Pathophysiology, and Pharmacological Treatment.CNS drugs · 2022Review
- Comment on: "Fluvoxamine for the Early Treatment of SARS-CoV-2 Infection: A Review of Current Evidence".Drugs · 2022Article
- Intersections between pneumonia, lowered oxygen saturation percentage and immune activation mediate depression, anxiety, and chronic fatigue syndrome-like symptoms due to COVID-19: A nomothetic network approach.Journal of affective disorders · 2022Article
- Risk factors for community-acquired pneumonia among inpatients with mental disorders in a tertiary general hospital.Frontiers in psychiatry · 2022Article
- Depressive Tendency and the Risk of Death from Pneumonia: The JACC Study.Internal medicine (Tokyo, Japan) · 2020Article
- Identification of psychiatric patients with high mortality and low medical utilization: a population-based propensity score-matched analysis.BMC health services research · 2020Article
- Longitudinal association between mental health and future antibiotic prescriptions in healthy adults: Results from the LOHAS.PloS one · 2020Article
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6 authors.
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Abstract
backgroundSome studies suggested that psychological stress may be associated with the severity and duration of infectious diseases. In this population-based study, we investigated associations between depressive disorder (DD) and pneumonia outcomes in Taiwan with a large-scale database from the National Health Insurance.
methodsOur study defined 112,198 patients who were hospitalized with a principal diagnosis of pneumonia. We defined their admission date for treatment of pneumonia as the index date. Subsequently, we selected 2,394 patients with DD within 3 years prior to their index date and 11,970 matched patients without DD. We carried out separate conditional logistic regressions to explore the association of clinical pneumonia treatment outcome (ICU admission, use of mechanical ventilation, acute respiratory failure and in-hospital death) with previously diagnosed DD.
resultsPatients with DD had a significantly higher probability of an intensive care unit admission (18.1% vs. 12.9%; p<0.001), need for mechanical ventilation (21.9% vs. 18.1%; p<0.001) and in-hospital death (10.4% vs. 9.0%; p = 0.025) than patients without DD. The study showed that pneumonia patients with DD were respectively 1.41- (95% CI: 1.25∼1.59, p<0.001), 1.28- (95% CI: 1.14∼1.43, p<0.001), and 1.17- times (95% CI: 1.01∼1.36, p = 0.039) greater odds of being admitted to the ICU, need for mechanical ventilation, and in-hospital death than patients without DD after adjusting for monthly income, urbanization level, geographic region and Charlson Comorbidity Index score.
conclusionsIn conclusion, we found that pneumonia patients with DD were associated with poor treatment outcomes compared to patients without DD.
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