Evidence map›Paper›PMID 25551279›Full record

ArticleBMC infectious diseases2014

Biopsy-proven autoimmune myocarditis in HIV-associated dilated cardiomyopathy.

Andrea Frustaci, Nicola Petrosillo, Marco Francone, Romina Verardo, Giuseppe Ippolito, Cristina Chimenti

Open access · goldAbstract readCase Reports
In one paragraph

Article in BMC infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Cardiac Autoimmunity: Myocarditis.Advances in experimental medicine and biology · 2017
    Review
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Andrea FrustaciBiocardiology Laboratory, National Institute for Infectious Diseases "Lazzaro Spallanzani", IRCCS, Via Portuense, 292, 00149, Rome, Italy. biocard@inmi.it.
Nicola PetrosilloBiocardiology Laboratory, National Institute for Infectious Diseases "Lazzaro Spallanzani", IRCCS, Via Portuense, 292, 00149, Rome, Italy. petrosillo@inmi.it.
Marco FranconeRadiological Sciences Department, "La Sapienza" University, Rome, Italy. marco.francone@uniroma1.it.
Romina VerardoBiocardiology Laboratory, National Institute for Infectious Diseases "Lazzaro Spallanzani", IRCCS, Via Portuense, 292, 00149, Rome, Italy. romina.verardo@inmi.it.
Giuseppe IppolitoBiocardiology Laboratory, National Institute for Infectious Diseases "Lazzaro Spallanzani", IRCCS, Via Portuense, 292, 00149, Rome, Italy. giuseppe.ippolito@inmi.it.
Cristina ChimentiBiocardiology Laboratory, National Institute for Infectious Diseases "Lazzaro Spallanzani", IRCCS, Via Portuense, 292, 00149, Rome, Italy. cristinachimenti@libero.it.
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani · ITSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDilated cardiomyopathy occurring in HIV-infected patients raises both diagnostic and therapeutic challenging problems. Indeed myocardial involvement in HIV infection has been variously attributed to several causes, including viral, toxic, nutritional and autoimmune, but no specific treatment capable to substantially improve patients' prognosis has been recognized so far. CASE PRESENTATION: Hereby we describe the case of an autoimmune myocarditis manifesting with heart failure in a3 9-year-old man with HIV infection. Left ventricular endomyocardial biopsy showed a lymphocytic myocarditis characterized by over-expression of HLA-DR and negative polymerase chain reaction for cardiotropic viruses. Steroid treatment was followed by recovery of cardiac dimension and function.

conclusionPresence of auto-reactive myocarditis should be considered in patients with HIV-associated dilated cardiomyopathy. Its recognition by endomyocardial biopsy followed by steroid administration may result in a complete resolution of cardiac disease.

Indexed as

AdultAutoimmune DiseasesBiopsyCardiomyopathy, DilatedHIV-1HIV InfectionsHumansMaleMyocarditisMyocardium

Identifiers

PMID25551279
PMCPMC4325940
OpenAlexW1997272780

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.