Evidence map›Paper›PMID 25551219›Full record

ArticlePloS one2014

In vivo effect of pneumonia on surfactant disaturated-phosphatidylcholine kinetics in newborn infants.

Maddalena Facco, Matteo Nespeca, Manuela Simonato, Ilena Isak, Giovanna Verlato, Gianluca Ciambra, Chiara Giorgetti, Virgilio P Carnielli, Paola E Cogo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. Trial
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  5. The Journal of biological chemistry · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Maddalena FaccoDepartment of Women's and Children's Health, University of Padua, Padua, Italy.
Matteo NespecaNeonatal Medicine, Salesi Children's Hospital, Polytechnic University of Marche and University of Ancona, Ancona, Italy.
Manuela SimonatoDepartment of Women's and Children's Health, University of Padua, Padua, Italy.
Ilena IsakDepartment of Women's and Children's Health, University of Padua, Padua, Italy.
Giovanna VerlatoDepartment of Women's and Children's Health, University of Padua, Padua, Italy.
Gianluca CiambraNeonatal Medicine, Salesi Children's Hospital, Polytechnic University of Marche and University of Ancona, Ancona, Italy.
Chiara GiorgettiNeonatal Medicine, Salesi Children's Hospital, Polytechnic University of Marche and University of Ancona, Ancona, Italy.
Virgilio P CarnielliNeonatal Medicine, Salesi Children's Hospital, Polytechnic University of Marche and University of Ancona, Ancona, Italy.
Paola E CogoPediatric Cardiac Anesthesia/Intensive Care Unit, Department of Pediatric Cardiology and Cardiac Surgery, Bambino Gesù Children's Hospital, Rome, Italy.
Marche Polytechnic University · ITUniversity of Padua · ITBambino Gesù Children's Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBacterial pneumonia in newborns often leads to surfactant deficiency or dysfunction, as surfactant is inactivated or its production/turnover impaired. No data are available in vivo in humans on the mechanism of surfactant depletion in neonatal pneumonia. We studied the kinetics of surfactant's major component, disaturated-phosphatidylcholine (DSPC), in neonatal pneumonia, and we compared our findings with those obtained from control newborn lungs.

methodsWe studied thirty-one term or near-term newborns (gestational age 39.7±1.7 weeks, birth weight 3185±529 g) requiring mechanical ventilation. Fifteen newborns had pneumonia, while 16 newborns were on mechanical ventilation but had no lung disease. Infants received an intratracheal dose of 13C labeled dipalmitoyl-phosphatidylcholine at the study start. We measured the amount and the isotopic enrichment of DSPC-palmitate from serial tracheal aspirates by gas chromatography and gas chromatography-mass spectrometry, respectively, and we calculated the DSPC half-life (HL) and pool size (PS) from the isotopic enrichment curves of surfactant DSPC-palmitate.

resultsThe mean DSPC amount obtained from all tracheal aspirates did not differ between the two groups. DSPC HL was 12.7 (6.5-20.2) h and 25.6 (17.9-60.6) h in infants with pneumonia compared with control infants (p = 0.003). DSPC PS was 14.1 (6.6-30.9) mg/kg in infants with pneumonia and 34.1 (25.6-65.0) mg/kg in controls, p = 0.042. Myeloperoxidase (MPO) activity, as a marker of lung inflammation, was 1322 (531-2821) mU/ml of Epithelial Lining Fluid (ELF) and 371(174-1080) mU/ml ELF in infants with pneumonia and in controls, p = 0.047. In infants with pneumonia, DSPC PS and HL significantly and inversely correlated with mean Oxygenation Index (OI) during the study (DSPC PS vs. OI R = -0.710, p = 0.004 and HL vs. OI R = -0.525, p = 0.044, respectively).

conclusionsWe demonstrated for the first time in vivo in humans that DSPC HL and PS were markedly impaired in neonatal pneumonia and that they inversely correlated with the degree of respiratory failure.

Indexed as

1,2-DipalmitoylphosphatidylcholineCase-Control StudiesDiagnostic Uses of ChemicalsFemaleGestational AgeHalf-LifeHumansInfant, NewbornInfant, PrematureLungMalePeroxidasePhosphatidylcholinesPneumoniaProspective StudiesRespiration, Artificial1,2-DipalmitoylphosphatidylcholineDiagnostic Uses of Chemicalslecithins, disaturatedPeroxidasePhosphatidylcholines

Identifiers

PMID25551219
PMCPMC4281094
OpenAlexW2067560979

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.