ArticleBMC neurology2014
The Dutch Parelsnoer Institute--Neurodegenerative diseases; methods, design and baseline results.
Article in BMC neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: An initiative of the Joint Programme for Neurodegenerative Disease Research.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2016Pooled it
- Critical and non-critical connections not differently associated with either Alzheimer's disease or vascular pathologies.medRxiv : the preprint server for health sciences · 2026Article
- Air pollution in relation to brain health indicators and global cognitive functioning in people with cardiovascular disorders along the heart-brain axis.Cerebral circulation - cognition and behavior · 2026Article
- Clinical definition, biological characterization, and detection guidelines of subjective cognitive decline due to Alzheimer's disease and related dementia: A position paper from ISTAART SCD PIA.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Towards a national registry for Alzheimer's disease and related dementias: rationale, design, and initial observations of the ABOARD cohort.Alzheimer's research & therapy · 2025Article
- Cerebral blood flow and cognitive functioning in patients undergoing transcatheter aortic valve implantation.EClinicalMedicine · 2025Article
- User Experience of a (Semi-) Automated Cognitive Phone-Based Assessment Within a Memory Clinic Population.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025Article
- Cerebrospinal fluid proteomic profiling of cognitively unimpaired individuals with suspected non-Alzheimer's disease pathophysiology.Brain communications · 2025Article
- The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment, the Excersion-VCI randomised controlled clinical trial.Cerebral circulation - cognition and behavior · 2025Article
- CSF proteomic profiles of neurodegeneration biomarkers in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Lower cerebral blood flow predicts cognitive decline in patients with vascular cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Functional network disruption in cognitively unimpaired autosomal dominant Alzheimer's disease: a magnetoencephalography study.Brain communications · 2024Article
- Alzheimer's Disease and Cognitive Decline in Patients with Cardiovascular Diseases Along the Heart-Brain Axis.Journal of Alzheimer's disease : JAD · 2024Article
- Small vessel disease burden and functional brain connectivity in mild cognitive impairment.Cerebral circulation - cognition and behavior · 2024Article
- Cardiac output, cerebral blood flow and cognition in patients with severe aortic valve stenosis undergoing transcatheter aortic valve implantation: design and rationale of the CAPITA study.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2023Article
- Linking self-perceived cognitive functioning questionnaires using item response theory: The subjective cognitive decline initiative.Neuropsychology · 2023Article
- Assessing subjective cognitive decline in older adults attending primary health care centers: what question should be asked?Journal of clinical and experimental neuropsychology · 2023Article
- Effects of the DICE Method to Improve Timely Recognition and Treatment of Neuropsychiatric Symptoms in Early Alzheimer's Disease at the Memory Clinic: The BEAT-IT Study.Journal of Alzheimer's disease : JAD · 2023Article
- Lower haemoglobin concentrations are associated with impaired cognition in patients with carotid artery occlusion.Cerebral circulation - cognition and behavior · 2023Article
- Plasma proteome profiling identifies changes associated to AD but not to FTD.Acta neuropathologica communications · 2022Article
Corrections and comments
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Authors and funding
17 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Parelsnoer Institute is a collaboration between 8 Dutch University Medical Centers in which clinical data and biomaterials from patients suffering from chronic diseases (so called "Pearls") are collected according to harmonized protocols. The Pearl Neurodegenerative Diseases focuses on the role of biomarkers in the early diagnosis, differential diagnosis and in monitoring the course of neurodegenerative diseases, in particular Alzheimer's disease. The objective of this paper is to describe the design and methods of the Pearl Neurodegenerative Diseases, as well as baseline descriptive variables, including their biomarker profile.
methodsThe Pearl Neurodegenerative Diseases is a 3-year follow-up study of patients referred to a memory clinic with cognitive complaints. At baseline, all patients are subjected to a standardized examination, including clinical data and biobank materials, e.g. blood samples, MRI and cerebrospinal fluid. At present, in total more than 1000 patients have been included, of which cerebrospinal fluid and DNA samples are available of 211 and 661 patients, respectively. First descriptives of a subsample of the data (n = 665) shows that patients are diagnosed with dementia (45%), mild cognitive impairment (31%), and subjective memory complaints (24%). DISCUSSION: The Pearl Neurodegenerative Diseases is an ongoing large network collecting clinical data and biomaterials of more than 1000 patients with cognitive impairments. The project has started with data analyses of the baseline characteristics and biomarkers, which will be the starting point of future specific research questions that can be answered by this unique dataset.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.