ArticleMolecules (Basel, Switzerland)2014
Characterization of ambrette seed oil and its mode of action in bacteria.
Article in Molecules (Basel, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- In Silico Evaluation of the Antimicrobial Activity of Thymol-Major Compounds in the Essential Oil ofMolecules (Basel, Switzerland) · 2022Article
- Metabolite Profile, Ruminal Methane Reduction, and Microbiome Modulating Potential of Seeds ofFrontiers in microbiology · 2022Article
- Green synthesis of silver nanoparticles using plant extracts and their antimicrobial activities: a review of recent literature.RSC advances · 2021Review
- Silver/Chitosan Nanocomposites: Preparation and Characterization and Their Fungicidal Activity against Dairy Cattle ToxicosisJournal of fungi (Basel, Switzerland) · 2020Article
- Essential Oil Composition ofMolecules (Basel, Switzerland) · 2019Article
- Silver nanopaticles synthesized using the seed extract ofSaudi journal of biological sciences · 2019Article
- Chemical composition, antioxidant activity and antibacterial mechanism of action from Marsilea minuta leaf hexane: methanol extract.Chemistry Central journal · 2018Article
- Mechanisms of Antibacterial Action of Quinoxaline 1,4-di-Frontiers in microbiology · 2016Article
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present study, chemical composition and the antibacterial mechanism of ambrette seed oil are investigated. Chemical composition of the oil was analysed by gas chromatography-mass spectrometry (GC-MS). Thirty-five compounds were identified and the major compounds were found to be farnesol acetate (51.45%) and ambrettolide (12.96%). The antibacterial activity was performed by well diffusion assay and the mechanisms were studied by measuring the alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and protein leakage assays. The antibacterial effect of the ambrette seed oil showed inhibitory effect against Bacillus subtilis, Staphylococcus aureus and Enterococcus faecalis. The LDH activity was high in all tested bacteria compared with control, whereas the ALP and protein concentrations were also increased in E. faecalis. Molecular docking revealed the ligands farnesol acetate and ambrettolide had satisfactory binding energy towards the beta lactamase TEM-72 and dihydrofolate reductase (DHFR) protein. Due to its better antibacterial properties, the ambrette seed oil could be used as a source of antibacterial agents.
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