ArticleJournal of the Royal Society, Interface2015
Robust and precise morphogen-mediated patterning: trade-offs, constraints and mechanisms.
Article in Journal of the Royal Society, Interface, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Position-dependent feedback drives scaling and robustness of morphogen gradients.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Bridging single cells to organs: Mesoscale modules as fundamental units of tissue function.Cell · 2025Review
- Dynamic readout of the Hh gradient in theeLife · 2024Article
- Morphogens in the evolution of size, shape and patterning.Development (Cambridge, England) · 2024Review
- Optimal performance objectives in the highly conserved bone morphogenetic protein signaling pathway.NPJ systems biology and applications · 2024Article
- Elucidating multi-input processing 3-node gene regulatory network topologies capable of generating striped gene expression patterns.PLoS computational biology · 2022Article
- Article
- Diversity and robustness of bone morphogenetic protein pattern formation.Development (Cambridge, England) · 2021Review
- Precision of tissue patterning is controlled by dynamical properties of gene regulatory networks.Development (Cambridge, England) · 2021Article
- Robustness of the Dorsal morphogen gradient with respect to morphogen dosage.PLoS computational biology · 2020Article
- The engineering principles of combining a transcriptional incoherent feedforward loop with negative feedback.Journal of biological engineering · 2019Article
- Programmed hierarchical patterning of bacterial populations.Nature communications · 2018Article
- Scaling of morphogenetic patterns in reaction-diffusion systems.Journal of theoretical biology · 2016Article
- A hybrid continuous-discrete method for stochastic reaction-diffusion processes.Royal Society open science · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The patterning of many developing tissues is organized by morphogens. Genetic and environmental perturbations of gene expression, protein synthesis and ligand binding are among the sources of unreliability that limit the accuracy and precision of morphogen-mediated patterning. While it has been found that the robustness of morphogen gradients to the perturbation of morphogen synthesis can be enhanced by particular mechanisms, how such mechanisms affect robustness to other perturbations, such as to receptor synthesis for the same morphogen, has been little explored. Here, we investigate the interplay between the robustness of patterning to the changes in receptor synthesis and morphogen synthesis and to the effects of cell-to-cell variability. Our analysis elucidates the trade-offs and constraints that arise as a result of achieving these three performance objectives simultaneously in the context of simple, steady-state morphogen gradients formed by diffusion and receptor-mediated uptake. Analysis of the interdependence between length scales of patterning and these performance objectives reveals several potential mechanisms for mitigating such trade-offs and constraints. One involves downregulation of receptor synthesis in the morphogen source, while another involves the presence of non-signalling cell-surface morphogen-binding molecules. Both of these mechanisms occur in Drosophila wing discs during their patterning. We computationally elucidate how these mechanisms improve the robustness and precision of morphogen-mediated patterning.
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