ReviewSaudi medical journal2014
Classification, clinical features, and genetics of neural tube defects.
Review in Saudi medical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Effect of Adherence to Mediterranean Diet during Pregnancy on Children's Health: A Systematic Review.Nutrients · 2019Pooled it
- Awareness and Use of Folic Acid Among Pregnant Women in Western Ukraine: A Pilot Study.International journal of environmental research and public health · 2026Article
- Burden of neural tube defects in the Middle East and North Africa from 1990 to 2021: Findings from the global burden of disease study.Journal of Taibah University Medical Sciences · 2025Article
- Arnold-Chiari Malformations in Pediatric Patients After Fetal Surgery for Meningomyelocele.Journal of clinical medicine · 2024Article
- Atretic cephalocele and differential considerations: A small case series.The neuroradiology journal · 2024Article
- Monosymmetros Cephalothoracopagus Tetrabrachius and Tetrapus Piglets with Syndromic Evolution.Animals : an open access journal from MDPI · 2024Article
- Dorsal ectopic breast-a cutaneous marker of occult spinal dysraphism.Journal of surgical case reports · 2024Article
- Craniorachischisis in a 33-week-old Female Fetus: A Case Report.Acta medica Philippina · 2024Article
- Exencephaly-Anencephaly Sequence Associated with Maxillary Brachygnathia, Spinal Defects, and Palatoschisis in a Male Domestic Cat.Animals : an open access journal from MDPI · 2023Article
- Maternal prenatal screening programs that predict trisomy 21, trisomy 18, and neural tube defects in offspring.PloS one · 2023Article
- Construction and predictive value of risk models of maternal serum alpha-fetoprotein variants and fetal open neural tube defects.Experimental biology and medicine (Maywood, N.J.) · 2022Article
- Expanding the clinical phenotype ofCold Spring Harbor molecular case studies · 2022Article
- Knowledge and Practice of Childbearing Women in Saudi Arabia towards Folic Acid Supplement-Evidence from a Cross-Sectional Study.Nutrients · 2022Article
- Neural tube defects: Different types and brief review of neurulation process and its clinical implication.Journal of family medicine and primary care · 2021Review
- Incidence of neural tube defects and their risk factors within a cohort of Moroccan newborn infants.BMC pediatrics · 2021Article
- New cut-off values for screening of trisomy 21, 18 and open neural tube defects (ONTD) during the second trimester in pregnant women with advanced maternal age.BMC pregnancy and childbirth · 2020Article
- Neonatal ten-year retrospective study on neural tube defects in a second level University Hospital.Italian journal of pediatrics · 2020Article
- Awareness and use of folic acid among women of childbearing age in Benue State, Nigeria.The Pan African medical journal · 2020Article
- Mediterranean diet, folic acid, and neural tube defects.Italian journal of pediatrics · 2017Review
- Risk factors associated with neural tube defects in infants referred to western Iranian obstetrical centers; 2013-2014.Electronic physician · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neural tube defects (NTDs) constitute a major health burden (0.5-2/1000 pregnancies worldwide), and remain a preventable cause of still birth, neonatal, and infant death, or significant lifelong handicaps. The malformations result from failure of the neural folds to fuse in the midline, and form the neural tube between the third and the fourth week of embryonic development. This review article discusses their classification, clinical features, and genetics. Most NTDs are sporadic and both genetic, and non-genetic environmental factors are involved in its etiology. Consanguinity was suggested to contribute to the high incidence of NTDs in several countries, including Saudi Arabia. Syndromes, often associated with chromosomal anomalies, account for <10% of all NTDs; but a higher proportion (20%) has been documented in Saudi Arabia. Genetic predisposition constitutes the major underlying risk factor, with a strong implication of genes that regulate folate one-carbon metabolism and planar cell polarity.
Indexed as
Identifiers
25551113PMC4362100W1480103818What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.