ReviewSaudi medical journal2014
Epidemiology, prenatal management, and prevention of neural tube defects.
Review in Saudi medical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Evaluating the potential role of determinants of health on encephalocele patient outcomes - a combined retrospective study and systematic review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Pooled it
- Prevalence of anencephaly in Africa: a systematic review and meta-analysis.Scientific reports · 2021Pooled it
- Birth prevalence of neural tube defects and associated risk factors in Africa: a systematic review and meta-analysis.BMC pediatrics · 2021Pooled it
- Neural tube defects burden from 1992 to 2021: a global, regional, and national age-period-cohort analysis of disability-adjusted life years.BMC pediatrics · 2026Article
- Spina Bifida Occulta, Syringomyelia, and Diastematomyelia in a Toddler: A Two-Year Case Report.The Yale journal of biology and medicine · 2026Article
- Maternal Folic Acid Supplementation and Neural Tube Defects in Northeast Iran: Insights for Developing Countries.Pediatric health, medicine and therapeutics · 2026Article
- Burden of neural tube defects in the Middle East and North Africa from 1990 to 2021: Findings from the global burden of disease study.Journal of Taibah University Medical Sciences · 2025Article
- Exploring Research Trends and Mechanisms: Maternal Diabetes and Neural Tube Defects (1991-2023).Journal of multidisciplinary healthcare · 2025Article
- Time to Death and Predictors Among Neonates with Neural Tube Defects in Two Public Hospitals, Addis Ababa, Ethiopia: A Retrospective Follow-Up Study.Pediatric health, medicine and therapeutics · 2025Article
- Craniorachischisis Totalis: A Detailed Case Report.Iranian journal of child neurology · 2025Article
- Article
- Neural Tube Defects and Folate Deficiency: Is DNA Repair Defective?International journal of molecular sciences · 2023Review
- A quest for genetic causes underlying signaling pathways associated with neural tube defects.Frontiers in pediatrics · 2023Review
- Neural tube defects among new borns: a cross-sectional study.Frontiers in pediatrics · 2023Article
- Whole exome sequencing identifies potential candidate genes for spina bifida derived from mouse models.American journal of medical genetics. Part A · 2022Article
- Overview of Neural Tube Defects: Gene-Environment Interactions, Preventative Approaches and Future Perspectives.Biomedicines · 2022Review
- A survey on women's awareness of iron and folic acid intake during preconception period and its associated factors in Manna District, Oromia region, Southwest Ethiopia.Nursing open · 2022Article
- Development and validation of preconception care improvement scale (PCIS) in a resource-limited setting.BMC pregnancy and childbirth · 2022Article
- Genetic Polymorphisms in DNA Repair Gene APE1/Ref-1 and the Risk of Neural Tube Defects in a High-Risk Area of China.Reproductive sciences (Thousand Oaks, Calif.) · 2021Article
- Pregnancy-Related Extracellular Vesicles Revisited.International journal of molecular sciences · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review article discusses the epidemiology, risk factors, prenatal screening, diagnosis, prevention potentials, and epidemiologic impact of neural tube defects (NTDs). The average incidence of NTDs is 1/1000 births, with a marked geographic variation. In the developed countries, the incidence of NTDs has fallen over recent decades. However, it still remains high in the less-developed countries in Latin America, Africa, the Middle East, Asia, and the Far East (>1 to 11/1000 births). Recognized NTDs risks include maternal diabetes, obesity, lower socioeconomic status, hyperthermia, and exposure to certain teratogens during the periconceptional period. Periconceptional folic acid supplementation decreased the prevalence of NTDs by 50-70%, and an obligatory folic acid fortification of food was adopted in several countries to reach women with unplanned pregnancies and those facing social deprivation. Prevention of NTDs can be accelerated if more, especially low income countries, adopted fortification of the staple food in their communities.
Indexed as
Identifiers
25551106PMC4362104What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.