ArticleJournal of diabetes and metabolic disorders2014
Lifestyle advice follow-up improve glycemic control, redox and inflammatory status in patients with type 2 diabetes.
Article in Journal of diabetes and metabolic disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Secondhand Smoke Correlates with Elevated Neutrophil-Lymphocyte Ratio and Has a Synergistic Effect with Physical Inactivity on Increasing Susceptibility to Type 2 Diabetes Mellitus: A Community-Based Case Control Study.International journal of environmental research and public health · 2020Article
- Reported Benefits of Insulin Therapy for Better Glycemic Control in Type 2 Diabetic Patients-Is This Applicable in Saudi Patients?Clinical medicine insights. Endocrinology and diabetes · 2016Article
- Knowledge, Attitude, and Self Care Practices Amongsts Patients WithType 2 Diabetes in Pakistan.Global journal of health science · 2015Article
- Association of Diabetic Neuropathy with Duration of Type 2 Diabetes and Glycemic Control.Cureus · 2015Article
- Cymene and Metformin treatment effect on biochemical parameters of male NMRI mice fed with high fat diet.Journal of diabetes and metabolic disorders · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe dietary composition associated to physical activity could play a significant role in improving insulin sensitivity and reducing risk of diabetes and its complications. This study was designed to investigate whether glycemic control, redox and inflammatory status impairments in patients with type 2 diabetes (T2D), were improved after 90 (d90) and 180 (d180) days follow-up of nutritional advices.
methodsPatients with T2D (n = 85) aged of 50 ± 8 years (Female/Male, 45/40), treated with oral antidiabetics (OAD) alone, with a body mass index (BMI) of 26 ± 2, were recruited. At the beginning of the study (d0), patients were instructed to follow-up nutritional advices adapted to T2D, and 30 to 45 min of walking per day. Assays were realized at d90 and d180 of follow-up. Data were compared by student 't' test and Pearson's correlation coefficients were determined between biochemical parameters and nutritional advices follow-up.
resultsReduced glycated haemoglobin (HbA1c), glucose and total cholesterol (TC) were noted in patients with T2D, at d90 and d180 compared to d0. Thiobarbituric acid reactive substances (TBARS) and hydroperoxyde levels were lower at d90 and d180 than d0. Serum nitric oxide (NO) was decreased at d180 compared to d0 and d90. In erythrocytes, superoxide dismutase (SOD) activity increased by 7% at d180 vs d0. Moreover, activity of glutathione peroxidase (GPx) enhanced (P < 0.05), whereas that of glutathione reductase (GRed) decreased (P < 0.001) at d90 vs d0. Resistin values were lower at d180 than d0 and d90 (P < 0.001). A progressive decrease in tumor necrosis factor-α (TNF-α) was observed at d90 and d180 vs d0.
conclusionNutritional advices associated to physical activity improve glycemic control, serum TC, redox and inflammatory status in T2D, in particular after 3 months of counseling. However, these results need to be supported with a longer dietary treatment and more rigorous control during the follow-up.
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