Evidence map›Paper›PMID 25550985›Full record

ArticleInternational journal of clinical and experimental medicine2014

Association between plasma homocysteine status and hypothyroidism: a meta-analysis.

Yande Zhou, Yufang Chen, Xueqin Cao, Chunfeng Liu, Ying Xie

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 5 pooled it
3.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 5 syntheses or guidelines pooled it, 38 citations in OpenAlex.

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  16. Thyroid and Cardiovascular Disease: Research Agenda for Enhancing Knowledge, Prevention, and Treatment.Thyroid : official journal of the American Thyroid Association · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yande ZhouDepartment of Endocrinology, The Second Affiliated Hospital of Soochow University Suzhou 215004, China.
Yufang ChenDepartment of Endocrinology, The Second Affiliated Hospital of Soochow University Suzhou 215004, China.
Xueqin CaoDepartment of Endocrinology, The Second Affiliated Hospital of Soochow University Suzhou 215004, China.
Chunfeng LiuDepartment of Neurology, The Second Affiliated Hospital of Soochow University Suzhou 215004, China ; Institute of Neuroscience, Soochow University Suzhou 215123, China.
Ying XieDepartment of Endocrinology, The Second Affiliated Hospital of Soochow University Suzhou 215004, China.
Soochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo figure out plasma homocysteine (Hcy) status in patients with subclinical hypothyroidism (SH) and overt hypothyroidism (OH) compared with healthy subjects, and the effect of levothyroxine (L-T4) on plasma homocysteine status in patients with hypothyroidism.

methodsPubMed Web of Science, and The Cochrane Library were used to identify eligible studies. The Newcastle-Ottawa Quality Assessment Scale was used to assess the quality of selected studies. All analyses were performed using the STATA, version 12 software.

resultsOur meta-analysis indicated that plasma Hcy concentrations elevated in OH patients without L-T4 treatment compared with healthy subjects. However, this elevation was not observed in the comparison between patients withSH without L-T4 treatment and healthy subjects. Moreover, plasma Hcy levels were found to be higher in patients with OH without L-T4 treatment than in patients with SH without L-T4 treatment. Finally, plasma Hcy concentrations decreased after L-T4 treatment in patients with SH or OH.

conclusionsPlasma Hcy status is associated with the severity of hypothyroidism and L-T4 treatment is helpful for patients with hypothyroidism to reduce the plasma Hcy levels.

Indexed as

Homocysteinelevothyroxinemeta-analysisovert hypothyroidismsubclinical hypothyroidism

Identifiers

PMID25550985
PMCPMC4276243
OpenAlexW1721664811

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.