Evidence map›Paper›PMID 25550929›Full record

ArticleInternational journal of clinical and experimental medicine2014

Effect of (-)-epigallocatechin-3-gallate in preventing bone loss in ovariectomized rats and possible mechanisms.

Dawei Song, Minfeng Gan, Jun Zou, Xuesong Zhu, Qin Shi, Huan Zhao, Zongping Luo, Wen Zhang, Shiyan Li, Junjie Niu and 5 more

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Dawei SongDepartment of Orthopedics, The First Affiliated Hospital of Soochow University No. 188, Shizi Street, Suzhou, Jiangsu Province, China.
Minfeng GanDepartment of Orthopedics, The First Affiliated Hospital of Soochow University No. 188, Shizi Street, Suzhou, Jiangsu Province, China.
Jun ZouDepartment of Orthopedics, The First Affiliated Hospital of Soochow University No. 188, Shizi Street, Suzhou, Jiangsu Province, China.
Xuesong ZhuDepartment of Orthopedics, The First Affiliated Hospital of Soochow University No. 188, Shizi Street, Suzhou, Jiangsu Province, China.
Qin ShiDepartment of Orthopedics, The First Affiliated Hospital of Soochow University No. 188, Shizi Street, Suzhou, Jiangsu Province, China.
Huan ZhaoDepartment of Orthopedics, The First Affiliated Hospital of Soochow University No. 188, Shizi Street, Suzhou, Jiangsu Province, China.
Zongping LuoDepartment of Orthopedics, The First Affiliated Hospital of Soochow University No. 188, Shizi Street, Suzhou, Jiangsu Province, China.
Wen ZhangDepartment of Orthopedics, The First Affiliated Hospital of Soochow University No. 188, Shizi Street, Suzhou, Jiangsu Province, China.
Shiyan LiDepartment of Orthopedics, The First Affiliated Hospital of Soochow University No. 188, Shizi Street, Suzhou, Jiangsu Province, China.
Junjie NiuDepartment of Orthopedics, The First Affiliated Hospital of Soochow University No. 188, Shizi Street, Suzhou, Jiangsu Province, China.
Hai ZhuDepartment of Orthopedics, The First Affiliated Hospital of Soochow University No. 188, Shizi Street, Suzhou, Jiangsu Province, China.
Hao ChenDepartment of Orthopedics, The First Affiliated Hospital of Soochow University No. 188, Shizi Street, Suzhou, Jiangsu Province, China.
Chenxi YuanDepartment of Orthopedics, The First Affiliated Hospital of Soochow University No. 188, Shizi Street, Suzhou, Jiangsu Province, China.
Xiaochen LiuDepartment of Orthopedics, The First Affiliated Hospital of Soochow University No. 188, Shizi Street, Suzhou, Jiangsu Province, China.
Huilin YangDepartment of Orthopedics, The First Affiliated Hospital of Soochow University No. 188, Shizi Street, Suzhou, Jiangsu Province, China.
Soochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledDespite recent developments reported in studies of (-)-epigallocatechin-3-gallate (EGCG), its early preventive effect of mitigating bone loss is not well understood. We investigated the effect of EGCG in preventing bone loss in ovariectomized (OVX) female rats, and explored the possible underlying mechanisms. Twelve-week-old female Sprague-Dawley rats, were divided into 3 groups: group A received intraperitoneal EGCG for 12 consecutive weeks, begun 3 days after ovariectomy; group B received ovariectomy alone; group C, received a sham operation. At the end of the experiment, tibias and femurs were harvested for: (1) micro-CT scanning and measurement of bone mineral density (BMD) and bone morphological parameters; (2) a 3-point bending test; (3) HE staining and an immunohistological study investigating Sema4D expression.

resultsThe BMD and BV/TV of group A were significantly higher than for the OVX group. The trabecular separation (Tb.Sp) of group A was significantly lower than for group B. RESULTS from the 3-point bending test showed no statistical significance among all the groups. Bone histological studies indicated that trabecular bone was denser in group C, while group B had less dense trabecular bone, and the bone morphological status of group A was intermediate between groups A and C. The immunohistological study demonstrated that Sema4D was more highly expressed as a percentage of the brown-stained area in group B than in the other 2 groups.

conclusionEGCG had a positive effect on mitigating bone loss in ovariectomized rats, and it inhibited Sema4D expression in bone tissue. Early stage supplementation of EGCG at a dose of 10 mg/kg/day after the onset of ovariectomy did not entirely eliminate bone loss.

Indexed as

BMDbone lossEGCGmicroarchitectureosteoporosisSema4D

Identifiers

PMID25550929
PMCPMC4276187
OpenAlexW2304070458

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.