ArticleInternational journal of clinical and experimental medicine2014
EphB4 expression in pterygium is associated with microvessel density.
Article in International journal of clinical and experimental medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Application of artificial intelligence models for detecting the pterygium that requires surgical treatment based on anterior segment images.Frontiers in neuroscience · 2022Article
- The Role of Eph Receptors and Ephrins in Corneal Physiology and Diseases.International journal of molecular sciences · 2021Review
- BMP6 Regulates Corneal Epithelial Cell Stratification by Coordinating Their Proliferation and Differentiation and Is Upregulated in Pterygium.Investigative ophthalmology & visual science · 2020Article
- YKL-40 expression in pterygium: a potential role in the pathogenesis.International ophthalmology · 2019Article
- Shear stress promotes differentiation of stem cells from human exfoliated deciduous teeth into endothelial cells via the downstream pathway of VEGF-Notch signaling.International journal of molecular medicine · 2018Article
- Proliferative Effects of Histamine on Primary Human Pterygium Fibroblasts.Mediators of inflammation · 2016Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
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Abstract
objectiveAngiogenesis is a key component of the pathogenesis process of pterygium, which is the growth of fibrovascular tissue on the cornea. It has been reported that EphB4, a receptor tyrosine kinase of the ephrin-Eph system, plays important role in vascular development during embryogenesis and tumor angiogenesis and is potentially involved in ocular angiogenesis. The aim of this study is to investigate the role of EphB4 in pterygia.
methodsFifteen pterygium samples and their paired upper bulbar conjunctiva were evaluated for expression of EphB4 and CD31 by using immunohistochemical staining. The expression level of the mRNA of EphB4 gene in 7 pterygia and matched upper bulbar conjunctiva was evaluated by using a quantitative real-time RT-PCR analysis. Microvessel density (MVD) was assessed with antibody that targets CD31.
resultsEphB4 protein was high expressed in the epithelium and stroma of pterygia compared to those in upper bulbar conjunctiva. Immunohistochemical staining showed that pterygia presented with statistically significant higher average count of microvessel compared to normal conjunctivae (28.24 ± 6.79 vs 11.09 ± 2.96 per high power field, P < 0.001). MVD values in stroma of the pterygium and normal conjunctiva presented a significant correlation with EphB4 staining (P < 0.001). Compared with autologous upper bulbar conjunctiva grafts, the expression of the EphB4 mRNA was increased in pterygia in 4 paired samples, including those 3 recurrent ones.
conclusionThe expression of EphB4 in pterygium was significantly related with the increased MVD and may be involved in angiogenesis. EphB4 protein is a potential target for treatment of pterygium.
Indexed as
Identifiers
25550909PMC4276167W1441936317What OpenQuestion holds
Registered trials
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