Polymorphisms in the PTX1 may not be associated with ischemic stroke susceptibility.

Heyin Mi, Wenli Hu

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Article in International journal of clinical and experimental medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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2 authors at 1 institution in 1 country.

Heyin MiDepartment of Neurology, Beijing Chao-Yang Hospital, Capital Medical University Beijing, China.

Wenli HuDepartment of Neurology, Beijing Chao-Yang Hospital, Capital Medical University Beijing, China.

Beijing Chao-Yang Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveIschemic stroke is a global health burden due to the increasingly higher incidence rate and mortality rate. Etiological research into the role of genetics in this heterogeneous disease may have diagnostic and prognostic implications. The present study was designed to assess the association between PTX1 SNPs: -717A>G and -286C>T>A, and ischemic stroke risk.

methodsRisk of ischemic stroke was estimated using summary ORs. The fixed effects model was performed in calculating the pooled ORs. All statistical data were analyzed with STATA software.

resultsWe combined 4,604 subjects for SNP -717A>G and 3,093 subjects for SNP -286C>T>A. SNP -717A>G was not found to be significantly associated with ischemic stroke risk (GG vs. AA, OR = 1.12, 95% CI = 0.83-1.50, PHet = 0.207; GG + GA vs. AA, OR = 1.04, 95% CI = 0.93-1.17, PHet = 0.533; GG vs. GA + AA, OR = 1.10, 95% CI = 0.82-1.47, PHet = 0.220). Meta-analysis of SNP -286C>T>A also demonstrated no statistical evidence of a significant association with ischemic stroke (AA vs. CC, OR = 0.86, 95% CI = 0.59-1.25, PHet = 0.348; AA vs. CC, OR = 0.92, 95% CI = 0.80-1.06, PHet = 0.609; AA vs. CC, OR = 0.89, 95% CI = 0.62-1.30, PHet = 0.374).

conclusionsThese results suggest that the PTX1 gene polymorphisms may not be associated with a predisposition to ischemic stroke.

Indexed as

ischemic strokepolymorphismPTX1

Identifiers

PMID25550907

PMCPMC4276165

OpenAlexW192729598

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.