Evidence map›Paper›PMID 25550889›Full record

ArticleInternational journal of clinical and experimental pathology2014

Function and subsets of dendritic cells and natural killer cells were decreased in gastric cancer.

Jianping Chen, Jing Yang, Jingting Jiang, Yun Zhuang, Wei He

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

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  6. The bioinformatics analysis of CD59 in Helicobacter pylori infected gastric cancer.Cancer biomarkers : section A of Disease markers · 2023
    Article
  7. Review
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  12. Article
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  15. C-C motif chemokine receptors in gastric cancer.Molecular and clinical oncology · 2018
    Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jianping ChenDepartment of Gastroenterology, The Third Affiliated Hospital of Soochow University, The First People's Hospital of Changzhou Changzhou, Jiangsu, China.
Jing YangDepartment of Gastroenterology, The Third Affiliated Hospital of Soochow University, The First People's Hospital of Changzhou Changzhou, Jiangsu, China.
Jingting JiangDepartment of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, The First People's Hospital of Changzhou Changzhou, Jiangsu, China.
Yun ZhuangDepartment of Gastroenterology, The Third Affiliated Hospital of Soochow University, The First People's Hospital of Changzhou Changzhou, Jiangsu, China.
Wei HeDepartment of Gastroenterology, The Third Affiliated Hospital of Soochow University, The First People's Hospital of Changzhou Changzhou, Jiangsu, China.
Soochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dendritic cells (DCs) and natural killer (NK) cells initiate specific immune responses against tumor cells. The aim of the present study was to determine the cytotoxicity and the subsets of the DC and NK cells and the cytokines level of DC and NK cells from cancer tissue and peripheral blood in the gastric cancer patients. Cytotoxicity of DC and NK was determined using the Cytotox non-radioactive assay. The cytotoxic activity of DC or NK isolated from cancer tissue and peripheral blood was attenuated in gastric cancer patients. CD11c, CD80, CD83, CD16, CD57 and CD69 were decreased in the cancer tissue and peripheral blood in the gastric cancer patients. CD86, CCR7 and CD59 were no significance in the cancer tissue and peripheral blood from gastric cancer patients. Tumor necrosis factor (TNF)-α, interleukin (IL)-2, T-bet and IL-15Rβ levels were decreased in DC and NK from the gastric cancer tissue and peripheral blood in the gastric cancer patients. IL-15 and IL-15Rα level were no significance in DC and NK in the gastric cancer tissue and peripheral blood in the gastric cancer patients. These results indicate that the cytotoxic activity and subsets and cytokines of DC and NK cells in the cancer tissue and peripheral blood in the gastric cancer patients were decreased. The decrease of subsets content and cytokines of DC and NK may contribute to a decrease in the function of DC and NK in the tissue and peripheral blood in the gastric cancer patients.

Indexed as

Antigens, CDBlotting, WesternCytokinesDendritic CellsFlow CytometryHumansImmunophenotypingKiller Cells, NaturalLymphocyte SubsetsStomach NeoplasmsAntigens, CDCytokinescytokinecytotoxicityDendritic cellnatural killer cell

Identifiers

PMID25550889
PMCPMC4270606
OpenAlexW2223773758

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.