Evidence map›Paper›PMID 25550839›Full record

ArticleInternational journal of clinical and experimental pathology2014

RVLM-IML pathway may implicate controlling peripheral airways by melanocortinergic-sympathetic signaling: a transneuronal labeling study using pseudorabies virus.

Cheng-Jin Yue, Li Feng, Qi Huang

Open access · greenAbstract read
In one paragraph

Article in International journal of clinical and experimental pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Autonomic control of energy balance and glucose homeostasis.Experimental & molecular medicine · 2022
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Cheng-Jin YueDepartment of Anesthesiology, Maternal and Child Health Hospital of Hubei Province Wuhan 430070, Hubei, People's Republic of China.
Li FengDepartment of Anesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030, Hubei, People's Republic of China.
Qi HuangDepartment of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030, Hubei, People's Republic of China.
Tongji Hospital · CNHubei Provincial Women and Children's Hospital · CN

Funding

ResourceP40OD010996 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STRICK, PETER · 2012 to 2024
$11.0M
NIH HHS P40 OD010996
6 · The paper itself

Abstract

Pseudorabies virus (PRV)-614 was injected into the tracheal wall of male MC4R-GFP transgenic mice, resulting in retrograde infections in spinal cord and autonomic premotor areas of the brain including the rostroventrolateral medulla (RVLM). This polysynaptic pathway to the airway may form the substrate underlying the impact of IML and RVLM on airway function. The neurochemical phenotype of MC4R-GFP-positive neurons was identified using fluorescence immunocytochemical labeling. PRV-614/MC4R-GFP dual labeled neurons were detected in spinal IML and the rostral ventrolateral medulla (RVLM). These data demonstrate the RVLM-IML pathway of synaptically connected neurons extending to the airway through melanocortinergic-sympathetic signaling.

Indexed as

RespirationAnimalsHerpesvirus 1, SuidMaleMedulla OblongataMiceNeural PathwaysNeuronsReceptor, Melanocortin, Type 4Signal TransductionSpinal CordSympathetic Nervous SystemMC4R protein, mouseReceptor, Melanocortin, Type 4autonomic nervous systemmelanocortin-4 receptorPeripheral airwaypseudorabies virusspinal cordthe rostroventrolateral medullatranssynaptic tracing

Identifiers

PMID25550839
PMCPMC4270583
OpenAlexW563147124

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.