Evidence map›Paper›PMID 25550836›Full record

ArticleInternational journal of clinical and experimental pathology2014

Significance of multidrug resistance gene-related proteins in the postoperative chemotherapy of gastric cancer.

Pengfei Yu, Yian Du, Litao Yang, Sunfu Fan, Jian Wu, Shusen Zheng

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
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  4. Article
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  6. Detection approaches for multidrug resistance genes of leukemia.Drug design, development and therapy · 2017
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Pengfei YuDepartment of Hepatobilliary and Pancreatic Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China; Department of Abdominal Surgery, Zhejiang Cancer Hospital, Hangzhou 310022, China.
Yian DuDepartment of Abdominal Surgery, Zhejiang Cancer Hospital Hangzhou 310022, China.
Litao YangDepartment of Abdominal Surgery, Zhejiang Cancer Hospital Hangzhou 310022, China.
Sunfu FanDepartment of Abdominal Surgery, Zhejiang Cancer Hospital Hangzhou 310022, China.
Jian WuDepartment of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University Hangzhou 310003, China.
Shusen ZhengDepartment of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University Hangzhou 310003, China.
Zhejiang Cancer Hospital · CNFirst Affiliated Hospital Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMultidrug resistance (MDR) is a serious problem in chemotherapy and is one of the main reasons for a poor outcome of gastric cancer. Study on the key proteins in multidrug resistance is necessary for the treatment of gastric cancer.

methodsThe expression of ToPo II, MRP and GST-π in 119 gastric cancers was retrospectively examined, and the results were analyzed in correlation with clinicopathological data. ToPo II negative, MRP positive and GST-π positive were regarded as three risk factors which may be associated with chemotherapy resistance and poor prognosis. Patients were divided into two groups: high-risk group (≥2 risk factors) and the low-risk group (<2 risk factors), and the tumor recurrence and patients' survival time of the two groups were also analyzed.

resultsThe positive rates of ToPo II, MRP and GST-π were 73.9%, 42.9% and 51.3%, respectively. The positively correlation between the expression of MRP and GST-π had been found. A significant correlation was shown between ToPo II expression and the level of differentiation. Significant differences with GST-π expression were also found in relation to the sex and differentiation. In the high-risk group, the 3-year survival rate of patients with/without chemotherapy were 62.1% and 52.0%, 5-year survival rates were 44.8% and 40.0%, but the difference was not statistically significant (P>0.05). In the low-risk group, the 3-year survival rate of patients with/without chemotherapy were 81.2% and 51.5%, 5-year survival rates were 71.9% and 45.5%, and the difference was statistically significant (P<0.05).

conclusionsCombined detection of MDR-related proteins ToPo II, MRP and GST-π may be prospectively valuable for postoperative individualized chemotherapy, and further predict the outcomes of gastric cancer patients.

Indexed as

AdultAgedAntineoplastic AgentsATP Binding Cassette Transporter, Subfamily B, Member 1DNA Topoisomerases, Type IIDrug Resistance, NeoplasmFemaleGlutathione S-Transferase piHumansMaleMiddle AgedPrognosisRetrospective StudiesStomach NeoplasmsSurvival RateAntineoplastic AgentsATP Binding Cassette Transporter, Subfamily B, Member 1DNA Topoisomerases, Type IIGlutathione S-Transferase pichemotherapymultidrug resistance-associated proteinsprognosisStomach neoplasms

Identifiers

PMID25550836
PMCPMC4270582
OpenAlexW1614525454

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.