ArticleInternational journal of clinical and experimental pathology2014
Aquaporin-8 mediates human esophageal cancer Eca-109 cell migration via the EGFR-Erk1/2 pathway.
Article in International journal of clinical and experimental pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- The role of Aquaporins in tumorigenesis: implications for therapeutic development.Cell communication and signaling : CCS · 2024Review
- AQP8 promotes glioma proliferation and growth, possibly through the ROS/PTEN/AKT signaling pathway.BMC cancer · 2023Article
- Aquaporins and Ion Channels as Dual Targets in the Design of Novel Glioblastoma Therapeutics to Limit Invasiveness.Cancers · 2023Review
- Aquaporin-mediated dysregulation of cell migration in disease states.Cellular and molecular life sciences : CMLS · 2023Review
- Aquaporins in Tumor.Advances in experimental medicine and biology · 2023Article
- Aquaporins in insulin resistance and diabetes: More than channels!Redox biology · 2021Review
- Aquaporin-8 is a novel marker for progression of human cervical cancer cells.Cancer biomarkers : section A of Disease markers · 2021Article
- Article
- OEsophageal Ion Transport Mechanisms and Significance Under Pathological Conditions.Frontiers in physiology · 2020Review
- Peroxiporins in Cancer.International journal of molecular sciences · 2019Review
- ROS from Physical Plasmas: Redox Chemistry for Biomedical Therapy.Oxidative medicine and cellular longevity · 2019Review
- Aquaporin 1 suppresses apoptosis and affects prognosis in esophageal squamous cell carcinoma.Oncotarget · 2018Article
- Down-regulation of CXCL11 inhibits colorectal cancer cell growth and epithelial-mesenchymal transition.OncoTargets and therapy · 2018Article
- AQP8 inhibits colorectal cancer growth and metastasis by down-regulating PI3K/AKT signaling and PCDH7 expression.American journal of cancer research · 2018Article
- Cancer: An Oxidative Crosstalk between Solid Tumor Cells and Cancer Associated Fibroblasts.BioMed research international · 2016Review
- Serum thymidine kinase 1 levels correlate with clinical characteristics of esophageal squamous cell carcinoma.International journal of clinical and experimental medicine · 2015Article
- Expression of aquaporins in intestine after heat stroke.International journal of clinical and experimental pathology · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Abnormal expression of aquaporins (AQPs) has been reported in several human cancers. Epidermal growth factor receptor (EGFR)-extracellular signal-regulated kinases1/2 (ERK1/2) are associated with tumorigenesis and cancer progression and may upregulate AQPs expression. In this study, we investigated acquaporin-8 expression and signaling via epidermal growth factor receptor-extracellular signal-regulated kinases1/2 in human esophageal cancer Eca-109 cells by western blot, immunofluorescence and wound healing (scratch) assays. Our results showed that epidermal growth factor (EGF) induced both Eca-109 migration and AQP8 expression. Wound healing results showed that cell migration was increased by 1.23-1.10-fold at 24 h and 48 h after EGF treatment. AQP8 expression was significantly increased (1.19-fold) at 48 h after EGF treatment in Eca-109. The EGFR kinase inhibitor, PD153035, blocked EGF-induced AQP8 expression and cell migration. AQP8 expression was decreased from 3.65-fold (EGF-treated) to 0.55-fold (PD153035-treated) in Eca-109. Furthermore, the MEK [MAPK (mitogen-activated protein kinase)/Erk1/2]/Erk1/2 inhibitor U0126 also inhibited EGF-induced AQP8 expression and cell migration. AQP8 expression was decreased from 3.92-fold (EGF-treated) to 1.38-fold (U0126-treated) in Eca-109. In conclusions, EGF induces AQP8 expression and cell migration in Eca-109 cells via the EGFR/Erk1/2 signal transduction pathway.
Indexed as
Identifiers
25550802PMC4270600W260290962What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.