ArticleInternational journal of clinical and experimental pathology2014
Adenoid cystic carcinoma of the tracheobronchial tree: clinicopathologic and immunohistochemical studies of 21 cases.
Article in International journal of clinical and experimental pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Solid-variant primary pulmonary adenoid cystic carcinoma with pleural metastasis and malignant pleural effusion: a rare case report.Frontiers in oncology · 2026Article
- Targeting MET and KRAS G12C co-occurring mutation in metastatic adenoid cystic carcinoma of the trachea: a case report.Journal of medical case reports · 2025Article
- The role of radiotherapy for patients with primary tracheal carcinoma: two case reports of tracheal carina squamous cell carcinoma and literature review.Frontiers in oncology · 2025Article
- A population study comparing tracheal and lung adenoid cystic carcinoma.Cancer medicine · 2024Article
- Primary pulmonary adenoid cystic carcinoma: A clinicopathological study of 64 patients.Thoracic cancer · 2024Article
- [Secondary or Second Primary Endotracheal Cancer after Surgery for Primary Lung Cancer: Case Series and Review of the Literature].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2023Review
- Pulmonary adenoid cystic carcinoma: molecular characteristics and literature review.Diagnostic pathology · 2023Review
- Clinical use ofTranslational lung cancer research · 2022Article
- Thyroid metastasis from adenoid cystic carcinoma of the lung: a case report and literature review.Journal of surgical case reports · 2021Article
- Tumor immune microenvironment and mutational analysis of tracheal adenoid cystic carcinoma.Annals of translational medicine · 2020Article
- ADENOID CYSTIC CARCINOMA OF DISTAL TRACHEA: A CASE REPORT.Acta clinica Croatica · 2019Article
- Proton Beam Therapy for Bronchogenic Adenoid Cystic Carcinoma: Dosimetry, Toxicities, and Outcomes.International journal of particle therapy · 2018Article
- Predictors of nodal metastasis and prognostic significance of lymph node ratio and total lymph node count in tracheobronchial adenoid cystic carcinoma.Cancer management and research · 2018Article
- Case report of apatinib mesylate treatment in rare advanced tracheal adenoid cystic carcinoma.Thoracic cancer · 2017Article
- Lung metastases from cutaneous adenoid cystic carcinoma 23 years after initial treatment.Respiratory medicine case reports · 2017Article
- Prognostic value of human papillomavirus infection and p53, p16, epidermal growth factor receptor and p34International journal of clinical and experimental pathology · 2017Article
- Tracheobronchial tumors.Journal of thoracic disease · 2016Review
- Molecular genetic studies on EGFR, KRAS, BRAF, ALK, PIK3CA, PDGFRA, and DDR2 in primary pulmonary adenoid cystic carcinoma.Diagnostic pathology · 2015Article
- Adenoid cystic carcinoma of the right main bronchus showing squamous differentiation and mimicking mucoepidermoid carcinoma: a case report.International journal of clinical and experimental pathology · 2015Article
- Adenoid Cystic Carcinoma of Trachea: Findings onIndian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, IndiaArticle
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Authors and funding
8 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
aimsTo review retrospectively 21 cases adenoid cystic carcinoma of the tracheobronchial tree (TACC) with emphasis on their clinical and pathologic features, treatment and the possible prognostic factors. METHODS AND
results21 cases TACC diagnosed by surgical biopsy or resection at the Peking Union Medical College Hospital (PUMCH) over 10 years. Patients aged 24-69 years (median, 49 years), 6 men/15 women. Cough (18/21), dyspnea (14/21) and hemoptysis (10/21) were the most frequent manifestations. 15 patients had tumors in trachea. Ten patients had pathologically positive margin (n = 11). Immunohistochemically, BCL-2, CD117, P16, type IV collagen, SMA and P63 were positive (20/20); GFAP was focally positive (4/20); TTF-1 and P53 were negative (0/20). Ki-67 index ranged from 2% to 35%. Fifteen patients had followed up, 13 of which received postoperative radiotherapy. The median relapse-free survival (RFS) was 56.9 months and the 5-year RFS was 48.6%. By univariate analysis, postoperative radiotherapy had favorable prognostic significance (P < 0.05).
conclusionsTACC, which is mainly located in primary trachea or bronchus, is difficult to be detected at early stage. The tumors are not likely to be completely removed by surgery, and postoperative radiotherapy is helpful for reducing the likelihood of recurrence and metastasis.
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25550788PMC4270623W2163110707What OpenQuestion holds
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