ArticleBeilstein journal of organic chemistry2014
A comparative study of the interactions of cationic hetarenes with quadruplex-DNA forming oligonucleotide sequences of the insulin-linked polymorphic region (ILPR).
Article in Beilstein journal of organic chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Studies on the Interactions of 3,11-Difluoro-6,8,13-trimethyl-8Molecules (Basel, Switzerland) · 2021Article
- Berberrubine Phosphate: A Selective Fluorescent Probe for Quadruplex DNA.Molecules (Basel, Switzerland) · 2021Article
- Synthesis and investigation of quadruplex-DNA-binding, 9-Beilstein journal of organic chemistry · 2020Article
- 8-Styryl-substituted coralyne derivatives as DNA binding fluorescent probes.RSC advances · 2017Article
- A Water-Soluble Tetraazaperopyrene Dye as Strong G-Quadruplex DNA Binder.Chemistry (Weinheim an der Bergstrasse, Germany) · 2016Article
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Authors and funding
4 authors.
Funding
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Abstract
The interactions of the ILPR sequence (ILPR = "insulin-linked polymorphic region") a2 [d(ACAG4TGTG4ACAG4TGTG4)] with [2.2.2]heptamethinecyanine derivatives 1a-e and with the already established quadruplex ligands coralyne (2), 3,3'-[2,6-pyridinediylbis(carbonylimino)]bis[1-methylquinolinium] (3), 4,4',4'',4'''-(21H,23H-porphine-5,10,15,20-tetrayl)tetrakis[1-methylpyridinium] (4), naphtho[2,1-b:3,4-b':6,5-b'':7,8-b''']tetraquinolizinium (5) and thiazole orange (6) were studied. It is demonstrated with absorption, fluorescence and CD spectroscopy that all investigated ligands bind with relatively high affinity to the ILPR-quadruplex DNA a2 (0.2-5.5 × 10(6) M(-1)) and that in most cases the binding parameters of ligand-ILPR complexes are different from the ones observed with other native quadruplex-forming DNA sequences.
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