ArticleProceedings of the National Academy of Sciences of the United States of America2015
The polarity of myxobacterial gliding is regulated by direct interactions between the gliding motors and the Ras homolog MglA.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- Using Single-Particle Fluorescence Microscopy to Quantify Substrate Binding of Peptidoglycan-Modification Enzymes.Bio-protocol · 2026Article
- Milestones in the development ofJournal of bacteriology · 2025Review
- A novel mechanism for bacterial sporulation based on programmed peptidoglycan degradation.bioRxiv : the preprint server for biology · 2025Article
- Autonomous division of the outer membrane in Gram-negative bacteria.bioRxiv : the preprint server for biology · 2025Article
- Structural model of a bacterial focal adhesion complex.Communications biology · 2025Article
- A lytic transglycosylase connects bacterial focal adhesion complexes to the peptidoglycan cell wall.eLife · 2024Article
- A lytic transglycosylase connects bacterial focal adhesion complexes to the peptidoglycan cell wall.bioRxiv : the preprint server for biology · 2024Article
- A molecular switch controls assembly of bacterial focal adhesions.Science advances · 2024Article
- Mathematical modeling of mechanosensitive reversal control inFrontiers in microbiology · 2023Article
- Flagellar Motor Transformed: Biophysical Perspectives of theFrontiers in microbiology · 2022Article
- ThemSystems · 2021Article
- Review
- Establishing rod shape from spherical, peptidoglycan-deficient bacterial spores.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- MotAB-like machinery drives the movement of MreB filaments during bacterial gliding motility.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Novel mechanisms power bacterial gliding motility.Molecular microbiology · 2016Review
- MglC, a Paralog of Myxococcus xanthus GTPase-Activating Protein MglB, Plays a Divergent Role in Motility Regulation.Journal of bacteriology · 2016Article
- Myxobacteria: Moving, Killing, Feeding, and Surviving Together.Frontiers in microbiology · 2016Review
- Lessons in Fundamental Mechanisms and Diverse Adaptations from the 2015 Bacterial Locomotion and Signal Transduction Meeting.Journal of bacteriology · 2015Review
- The small G-protein MglA connects to the MreB actin cytoskeleton at bacterial focal adhesions.The Journal of cell biology · 2015Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Gliding motility in Myxococcus xanthus is powered by flagella stator homologs that move in helical trajectories using proton motive force. The Frz chemosensory pathway regulates the cell polarity axis through MglA, a Ras family GTPase; however, little is known about how MglA establishes the polarity of gliding, because the gliding motors move simultaneously in opposite directions. Here we examined the localization and dynamics of MglA and gliding motors in high spatial and time resolution. We determined that MglA localizes not only at the cell poles, but also along the cell bodies, forming a decreasing concentration gradient toward the lagging cell pole. MglA directly interacts with the motor protein AglR, and the spatial distribution of AglR reversals is positively correlated with the MglA gradient. Thus, the motors moving toward lagging cell poles are less likely to reverse, generating stronger forward propulsion. MglB, the GTPase-activating protein of MglA, regulates motor reversal by maintaining the MglA gradient. Our results suggest a mechanism whereby bacteria use Ras family proteins to modulate cellular polarity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.