ArticleProceedings of the National Academy of Sciences of the United States of America2015
Dialkylresorcinols as bacterial signaling molecules.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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60 citing papers in PubMed.
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- Pseudovibriamides frommBio · 2025Article
- The pharmacokinetics of hexylresorcinol-containing lozenges and their antimicrobial efficacy against oral and respiratory microorganisms.Journal of oral microbiology · 2025Article
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- Quorum sensing in bacteria: in silico protein analysis, ecophysiology, and reconstruction of their evolutionary history.BMC genomics · 2024Article
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- Constructions of quorum sensing signaling network for activated sludge microbial community.ISME communications · 2024Article
- Insecticidal features displayed by the beneficial rhizobacterium Pseudomonas chlororaphis PCL1606.International microbiology : the official journal of the Spanish Society for Microbiology · 2022Article
- Exploring AI-2-mediated interspecies communications within rumen microbial communities.Microbiome · 2022Article
- Microalgae and Bacteria Interaction-Evidence for Division of Diligence in the Alga Microbiota.Microbiology spectrum · 2022Article
- Deciphering Chemical Mediators Regulating Specialized Metabolism in a Symbiotic Cyanobacterium.Angewandte Chemie (International ed. in English) · 2022Article
- Machine learning aided construction of the quorum sensing communication network for human gut microbiota.Nature communications · 2022Article
- The role of bacterial signaling networks in antibiotics response and resistance regulation.Marine life science & technology · 2022Review
- Interplay between the microalgaeFrontiers in microbiology · 2022Article
- Comparative genomic and functional analysis ofFrontiers in microbiology · 2022Article
- Quorum sensing in human gut and food microbiomes: Significance and potential for therapeutic targeting.Frontiers in microbiology · 2022Review
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
It is well recognized that bacteria communicate via small diffusible molecules, a process termed quorum sensing. The best understood quorum sensing systems are those that use acylated homoserine lactones (AHLs) for communication. The prototype of those systems consists of a LuxI-like AHL synthase and a cognate LuxR receptor that detects the signal. However, many proteobacteria possess LuxR receptors, yet lack any LuxI-type synthase, and thus these receptors are referred to as LuxR orphans or solos. In addition to the well-known AHLs, little is known about the signaling molecules that are sensed by LuxR solos. Here, we describe a novel cell-cell communication system in the insect and human pathogen Photorhabdus asymbiotica. We identified the LuxR homolog PauR to sense dialkylresorcinols (DARs) and cyclohexanediones (CHDs) instead of AHLs as signals. The DarABC synthesis pathway produces the molecules, and the entire system emerged as important for virulence. Moreover, we have analyzed more than 90 different Photorhabdus strains by HPLC/MS and showed that these DARs and CHDs are specific to the human pathogen P. asymbiotica. On the basis of genomic evidence, 116 other bacterial species are putative DAR producers, among them many human pathogens. Therefore, we discuss the possibility of DARs as novel and widespread bacterial signaling molecules and show that bacterial cell-cell communication goes far beyond AHL signaling in nature.
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