ReviewPharmacology & therapeutics2015
Virus-induced modulation of lower airway diseases: pathogenesis and pharmacologic approaches to treatment.
Review in Pharmacology & therapeutics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 44 citations in OpenAlex.
- Reducing Hospital Readmissions in Chronic Obstructive Pulmonary Disease Patients: Current Treatments and Preventive Strategies.Medicina (Kaunas, Lithuania) · 2025Review
- Quantifying Rhinovirus Genomic and Negative-Strand RNA by RT-PCR.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Drugs Used in the Treatment of Viral Infections for the Prevention of Airway Remodeling in Asthma.Mediators of inflammation · 2025Review
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- Article
- Respiratory Viral and Bacterial Exacerbations of COPD-The Role of the Airway Epithelium.Cells · 2022Review
- Patient-Centered Discussion on End-of-Life Care for Patients with Advanced COPD.Medicina (Kaunas, Lithuania) · 2022Review
- Bacterial and viral infections and related inflammatory responses in chronic obstructive pulmonary disease.Annals of medicine · 2021Review
- Human Rhinoviruses in Adult Patients in a Tertiary Care Hospital in Germany: Molecular Epidemiology and Clinical Significance.Viruses · 2021Article
- Association of serum uric acid levels with COVID-19 severity.BMC endocrine disorders · 2021Article
- Specific Assay of Negative Strand Template to Quantify Intracellular Levels of Rhinovirus Double-Stranded RNA.Methods and protocols · 2021Article
- Rhinovirus Induces Basolateral Release of IL-17C in Highly Differentiated Airway Epithelial Cells.Frontiers in cellular and infection microbiology · 2020Article
- Pellino-1 Regulates the Responses of the Airway to Viral Infection.Frontiers in cellular and infection microbiology · 2020Article
- Editorial: The Response of Mucosal Epithelial Cells to Infections.Frontiers in cellular and infection microbiology · 2020Article
- Upregulation of cell-surface mucin MUC15 in human nasal epithelial cells upon influenza A virus infection.BMC infectious diseases · 2019Article
- Reverse Genetics and Rhinovirus-A New Approach to an Old Problem?The Journal of infectious diseases · 2019Article
- Lower Airway Virology in Health and Disease-From Invaders to Symbionts.Medicina (Kaunas, Lithuania) · 2018Review
- Interferon response to respiratory syncytial virus by bronchial epithelium from children with asthma is inversely correlated with pulmonary function.The Journal of allergy and clinical immunology · 2018Article
- Tumor necrosis factor family member LIGHT acts with IL-1β and TGF-β to promote airway remodeling during rhinovirus infection.Allergy · 2018Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Uncomplicated upper respiratory viral infections are the most common cause of days lost from work and school and exert a major economic burden. In susceptible individuals, however, common respiratory viruses, particularly human rhinoviruses, also can have a major impact on diseases that involve the lower airways, including asthma, chronic obstructive pulmonary diseases (COPD) and cystic fibrosis (CF). Respiratory virus-induced wheezing illnesses in early life are a significant risk factor for the subsequent development of asthma, and virus infections may also play a role in the development and progression of airway remodeling in asthma. It is clear that upper respiratory tract virus infections can spread to the lower airway and trigger acute attacks of asthma, COPD or CF. These exacerbations can be life-threatening, and exert an enormous burden on health care systems. In recent years we have gained new insights into the mechanisms by which respiratory viruses may induce acute exacerbations of lower airway diseases, as well as into host defense pathways that may regulate the outcomes to viral infections. In the current article we review the role of viruses in lower airway diseases, including our current understanding on pathways by which they may cause remodeling and trigger acute exacerbations. We also review the efficacy of current and emerging therapies used to treat these lower airway diseases on the outcomes due to viral infection, and discuss alternative therapeutic approaches for the management of virus-induced airway inflammation.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.