ArticleBritish journal of pharmacology1989
Caffeine-induced inhibition of calcium channel current in cultured smooth cells from pregnant rat myometrium.
Article in British journal of pharmacology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 45 citations in OpenAlex.
- Antispasmodic Activity of Light-Roasted Coffee Extract and Its Potential Use in Gastrointestinal Motility Disorders.Foods (Basel, Switzerland) · 2024Article
- 8-Oxo-9-Dihydromakomakine Isolated fromMolecules (Basel, Switzerland) · 2018Article
- Caffeine's Vascular Mechanisms of Action.International journal of vascular medicine · 2010Article
- The effects of caffeine on ATP-sensitive K(+) channels in smooth muscle cells from pig urethra.British journal of pharmacology · 2000Article
- Possible mechanism of the potent vasoconstrictor actions of ryanodine on femoral arteries from spontaneously hypertensive rats.British journal of pharmacology · 1996Article
- Voltage-dependent suppression of calcium current by caffeine in single smooth muscle cells of the guinea-pig urinary bladder.Naunyn-Schmiedeberg's archives of pharmacology · 1996Article
- Effects of caffeine on cytoplasmic free Ca2+ concentration in pancreatic beta-cells are mediated by interaction with ATP-sensitive K+ channels and L-type voltage-gated Ca2+ channels but not the ryanodine receptor.The Biochemical journal · 1995Article
- Influence of calcium on the effects of okadaic acid and its interaction with caffeine and theophylline in rat myometrium.Naunyn-Schmiedeberg's archives of pharmacology · 1994Article
- Evidence for multiple open states of the Ca2+ channels in smooth muscle cells isolated from the guinea-pig detrusor.The Journal of physiology · 1993Article
- Effects of excitatory neurotransmitters on Ca2+ channel current in smooth muscle cells isolated from guinea-pig urinary bladder.British journal of pharmacology · 1993Article
- Multiple effects of caffeine on calcium current in rat ventricular myocytes.Pflugers Archiv : European journal of physiology · 1993Article
- Mechanisms of caffeine-induced contraction and relaxation of rat aortic smooth muscle.The Journal of physiology · 1992Article
- Pharmacological block of Ca(2+)-activated Cl- current in rat vascular smooth muscle cells in short-term primary culture.Pflugers Archiv : European journal of physiology · 1991Article
- Mechanisms controlling caffeine-induced relaxation of coronary artery of the pig.British journal of pharmacology · 1991Article
- The action of caffeine on inward barium current through voltage-dependent calcium channels in single rabbit ear artery cells.Pflugers Archiv : European journal of physiology · 1990Article
- Role of Various Potassium Channels in Caffeine-induced Aortic Relaxation in Rats.Saudi journal of medicine & medical sciencesArticle
- Caffeine inhibits InsP3 responses and capacitative calcium entry in canine pulmonary arterial smooth muscle cells.Vascular pharmacologyArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The inhibitory effect of caffeine on the calcium channel current was investigated in cultured myometrial cells isolated from pregnant rats. 2. Caffeine inhibited the calcium channel current elicited from a holding potential of -70 mV in a concentration-dependent manner. The IC50 was estimated to be 35 mM. 3. The caffeine inhibition was not enhanced when calcium channels were opened by a conditioning depolarizing pulse sequence or when the number of inactivated calcium channels was increased at depolarized holding potentials. 4. Caffeine antagonized the specific binding of (+)-[3H]-isradipine to myometrial membranes. The IC50 value found in binding experiments was similar to the IC50 value for half-maximal inhibition of calcium channel current. Caffeine decreased the maximal binding capacity of (+)-[3H]-isradipine to myometrial membranes without any significant change in the dissociation constant. 5. The results indicate that caffeine interacts with a site closely associated with the voltage-dependent calcium channels in myometrial cells and, in turn, inhibits calcium influx.
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