Evidence map›Paper›PMID 25549890›Full record

ReviewNature reviews. Molecular cell biology2015

In the right place at the right time: visualizing and understanding mRNA localization.

Adina R Buxbaum, Gal Haimovich, Robert H Singer

Erratum issuedAbstract readReview
In one paragraph

Review in Nature reviews. Molecular cell biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 315 papers.

0numbers the graph read from it
0cells of the map it votes in
315citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

315 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. The KIF6-RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  6. Article
  7. Subcellularly Resolved 3D Translatome in Mouse Oocytes and Early Embryos.bioRxiv : the preprint server for biology · 2026
    Article
  8. Review
  9. Review
  10. Review
  11. ACS omega · 2026
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Investigating Potential 5' UTR G-Quadruplexes Within NRF2 mRNA.Current issues in molecular biology · 2026
    Article
  18. Active transport of tRNAs facilitates distributed protein synthesis.bioRxiv : the preprint server for biology · 2026
    Article
  19. Article
  20. RNA variation as the driver of genomic efficiency and phenotypic complexity.International journal of biological sciences · 2026
    Review

255 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Adina R Buxbaum1] Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA. [2] Gruss Lipper Biophotonics Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA. [3].
Gal Haimovich1] Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA. [2] Gruss Lipper Biophotonics Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA. [3] Department of Molecular Genetics, Weizmann Institute of Science, 234 Herzl Street, Rehovot 7610001, Israel. [4].
Robert H Singer1] Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA. [2] Gruss Lipper Biophotonics Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA. [3] Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA.

Funding

Mechanism of MRNA Localization and Localized Translation in NeuronsR01NS083085 · NINDS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Sulagna Das, Robert H Singer · 2013 to 2026
$9.0M
RNA TRANSPORT AND LOCALIZATION IN YEAST IN SITUR01GM057071 · NIGMS · YESHIVA UNIVERSITY · PI SINGER, ROBERT H · 1998 to 2019
$5.7M
Imaging Transcription in Living AnimalsR01EB013571 · NIBIB · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI SINGER, ROBERT H · 2012 to 2015
$2.4M
NIBIB NIH HHS 5R01EB013571NIBIB NIH HHS R01 EB013571NIGMS NIH HHS 2R01GM057071NIGMS NIH HHS R01 GM057071NINDS NIH HHS 9R01NS083085NINDS NIH HHS R01 NS083085
6 · The paper itself

Abstract

The spatial regulation of protein translation is an efficient way to create functional and structural asymmetries in cells. Recent research has furthered our understanding of how individual cells spatially organize protein synthesis, by applying innovative technology to characterize the relationship between mRNAs and their regulatory proteins, single-mRNA trafficking dynamics, physiological effects of abrogating mRNA localization in vivo and for endogenous mRNA labelling. The implementation of new imaging technologies has yielded valuable information on mRNA localization, for example, by observing single molecules in tissues. The emerging movements and localization patterns of mRNAs in morphologically distinct unicellular organisms and in neurons have illuminated shared and specialized mechanisms of mRNA localization, and this information is complemented by transgenic and biochemical techniques that reveal the biological consequences of mRNA mislocalization.

Indexed as

AnimalsBiological TransportHumansNeuronsProtein BiosynthesisProtein TransportRNA, MessengerRNA, Messenger

Identifiers

PMID25549890
PMCPMC4484810

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.