ArticleThyroid : official journal of the American Thyroid Association2015
Adult mice lacking the type 2 iodothyronine deiodinase have increased subchondral bone but normal articular cartilage.
Article in Thyroid : official journal of the American Thyroid Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 27 citations in OpenAlex.
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- Higher Peripheral Thyroid Sensitivity Is Linked to a Lower Risk of Heart Failure After Acute Myocardial Infarction.The Journal of clinical endocrinology and metabolism · 2023Article
- Effect of Hypothyroidism on Complications in Patients Undergoing TKA in Indian Population.Indian journal of orthopaedics · 2023Article
- Levothyroxine use and longitudinal changes in thigh muscles in at-risk participants for knee osteoarthritis: preliminary analysis from Osteoarthritis Initiative cohort.Arthritis research & therapy · 2023Article
- How does Hashimoto's thyroiditis affect bone metabolism?Reviews in endocrine & metabolic disorders · 2023Review
- Identification of polymorphic loci in the deiodinase 2 gene and their associations with head dimensions in geese.Animal bioscience · 2022Article
- Endocrine Regulation on Bone by Thyroid.Frontiers in endocrinology · 2022Review
- Accelerating functional gene discovery in osteoarthritis.Nature communications · 2021Article
- Paradigms of Dynamic Control of Thyroid Hormone Signaling.Endocrine reviews · 2019Review
- The potent anti-inflammatory effect of Guilu Erxian Glue extracts remedy joint pain and ameliorate the progression of osteoarthritis in mice.Journal of orthopaedic surgery and research · 2018Article
- Hypothyroidism Increases 90-Day Complications and Costs Following Primary Total Knee Arthroplasty.The Journal of arthroplasty · 2018Article
- Incidence of total hip or knee replacement due to osteoarthritis in relation to thyroid function: a prospective cohort study (The Nord-Trøndelag Health Study).BMC musculoskeletal disorders · 2017Article
- New insights into thyroid hormone action.Pharmacology & therapeutics · 2017Review
- Role of Thyroid Hormones in Skeletal Development and Bone Maintenance.Endocrine reviews · 2016Review
- Novel Insights into Osteoarthritis Joint Pathology from Studies in Mice.Current rheumatology reports · 2015Review
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3 authors at 1 institution in 1 country.
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Abstract
backgroundAlthough osteoarthritis (OA) is the commonest joint disorder and has a rising prevalence as the population ages, no drugs are available that prevent or delay the onset and progression of disease. Recent studies identified the DIO2 gene encoding type 2 deiodinase (D2) as a susceptibility locus for OA, and further data suggest deiodinase-regulated local availability of triiodothyronine (T3) in the joint plays an important role in cartilage maintenance and repair. To investigate the hypothesis that reduced tissue T3 availability protects joints from development of OA, the joint phenotypes of adult mice lacking D2 (D2KO) or lacking both D1 and D2 (D1D2KO), the only enzymes that catalyze conversion of the prohormone thyroxine to active T3, were determined.
methodsKnee joints were prepared from male 16-week-old adult wild type (WT; n=9), D2KO (n=5), and D1D2KO (n=3) mice. Articular cartilage pathology was scored using the Osteoarthritis Research Society International (OARSI) histopathology scale for murine OA to determine the severity and extent of disease. Digital X-ray microradiography was used to determine the area and mineral content of subchondral bone immediately beneath the articular cartilage surface.
resultsThere were no differences in maximum and standardized OA scores, cartilage erosion indices, or articular cartilage cellularity among WT, D2KO, and D1D2KO mice. Subchondral bone area did not differ among genotypes, but mineral content was markedly increased in both D2KO and D1D2KO mice compared to WT.
conclusionsAlthough adult D2KO mice have normal articular cartilage and no other features of spontaneous joint damage, they exhibit increased subchondral bone mineral content.
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