ArticlePloS one2014
Exercises in hot and humid environment caused liver injury in a rat model.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- A Handful of Details to Ensure the Experimental Reproducibility on the FORCED Running Wheel in Rodents: A Systematic Review.Frontiers in endocrinology · 2021Pooled it
- Air Pressure, Humidity and Stroke Occurrence: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2016Pooled it
- Trial
- Heat and humidity stress aggravate high-fat diet-induced kidney damage in albino rats.Biologia futura · 2026Article
- Article
- The Role of Key Molecules of Pyroptosis in Liver Damage of Rats With Exertional Heat Stroke.Gastroenterology research and practice · 2025Article
- Article
- Proposal of New Safety Limits for In Vivo Experiments of Magnetic Hyperthermia Antitumor Therapy.Cancers · 2022Article
- A mouse model of exertional heatstroke-related acute kidney injury.Annals of translational medicine · 2022Article
- Altered relationship between gluconeogenesis and immunity in broilers exposed to heat stress for different durations.Poultry science · 2021Article
- The 6-week Effects of HIIT on Biomarkers of Tissue and Oxidative Damage in Wistar Rats Previously Supplemented with Pyridoxine.International journal of exercise science · 2021Article
- Serum biochemistry ofVeterinary world · 2020Article
- Neuroendocrine Whiplash: Slamming the Breaks on Anabolic-Androgenic Steroids Following Repetitive Mild Traumatic Brain Injury in Rats May Worsen Outcomes.Frontiers in neurology · 2019Article
- Whey Protein Improves Marathon-Induced Injury and Exercise Performance in Elite Track Runners.International journal of medical sciences · 2017Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate injury pattern during intense exercises in hot and humid environment particularly on liver in a rat exertional heat stroke model.
methodsWe randomly divided 30 rats into a control group (CG), a normal temperature (25±2°C, 60%±5% humidity) exercise group (NTEG) and a high temperature and high humidity (35±2°C, 80%±10% humidity) exercising group (HTEG), each comprising 10 animals. The NTEG and HTEG rats were forced to run in a treadmill for 1 hour maximum at 20 rpm. We analyzed liver cells of all three groups with JC-1 dye and flow cytometry for apoptosis rates in addition to liver tissue 8 - hydroxy deoxyguanosine (8 - OhdG) and blood serum IL-6, tumor necrosis factor alpha (TNF-α), alanine aminotransferase ALT, aspartate amino transferase (AST), serum creatinine (CREA), blood urea nitrogen (BUN), lactate dehydrogenase (LDH), creatine phosphate kinase (CK) concentrations.
resultCompared with NTEG rats, beside reduced exercise tolerance (60±5 vs. 15±3 minutes) (p = 0.002) the 8-OhdG liver tissue concentrations were significantly higher (p = 0.040) in the HTEG rats. The HTEG developed more organ tissue damage and cellular fragmentations of liver cells. In both exercise groups TNF-α and IL-6 serum concentrations were enhanced significantly (p<0.001) being highest in the HTEG animals. Serum ALT, AST, LDH, CREA, BUN and CK concentrations were significantly enhance in both exercise groups.
conclusionIn our exertional heat stroke rat model, we found tissue damage particularly in livers during exercises in hot and humid environment that was related to inflammation, oxidative stress and apoptosis.
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