ArticleJournal of breast cancer2014
Subtype is a predictive factor of nonsentinel lymph node involvement in sentinel node-positive breast cancer patients.
Article in Journal of breast cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- A study on predicting additional axillary lymph node positivity in breast cancer patients with positive sentinel lymph node to avoid axillary lymph node dissection.Gland surgery · 2026Article
- A preoperative prediction model for ipsilateral axillary lymph node metastasis of breast cancer based on clinicopathological and ultrasonography features: a prospective cohort study.Frontiers in oncology · 2025Article
- Article
- Association between postoperative pathological results and non-sentinel nodal metastasis in breast cancer patients with sentinel lymph node-positive breast cancer.World journal of surgical oncology · 2024Article
- Ultrasonography and clinicopathological features of breast cancer in predicting axillary lymph node metastases.BMC cancer · 2022Article
- A novel nomogram for decision-making assistance on exemption of axillary lymph node dissection in T1-2 breast cancer with only one sentinel lymph node metastasis.Frontiers in oncology · 2022Article
- Relation Between Tumor Size and Lymph Node Metastasis According to Subtypes of Breast Cancer.Journal of breast cancer · 2021Article
- Imaging Predictors for Nonsentinel Lymph Node Metastases in Breast Cancer Patients.Breast care (Basel, Switzerland) · 2020Article
- Sentinel Node Biopsy in Early Breast Cancer Patients with Palpable Axillary Node.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- Analysis of factors related to non-sentinel lymph node metastasis in 296 sentinel lymph node-positive Chinese breast cancer patients.Cancer biology & medicine · 2018Article
- Impact of Size of the Tumour, Persistence of Estrogen Receptors, Progesterone Receptors, HER2Neu Receptors and Ki67 Values on Positivity of Axillary Lymph Nodes in Patients with Early Breast Cancer with Clinically Negative Axillary Examination.Open access Macedonian journal of medical sciences · 2017Article
- Factors Influencing Non-sentinel Node Metastasis in Patients with Macrometastatic Sentinel Lymph Node Involvement and Validation of Three Commonly Used Nomograms.European journal of breast health · 2017Article
- Expression of SIRT1 and apoptosis-related proteins is predictive for lymph node metastasis and disease-free survival in luminal A breast cancer.Virchows Archiv : an international journal of pathology · 2015Article
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4 authors.
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Abstract
purposeThis study aimed to identify the effect of breast cancer subtype on nonsentinel lymph node (NSLN) metastasis in patients with a positive sentinel lymph node (SLN).
methodsThe records of 104 early breast cancer patients with a positive SLN between April 2009 and September 2013 were retrospectively evaluated. All patients underwent axillary lymph node dissection. The effects of the tumor subtype (luminal A, luminal/HER2+, human epidermal growth factor receptor 2 [HER2] overexpression, and triple-negative) and other clinicopathological factors on NSLN metastasis were examined by univariate and multivariate statistical analyses.
resultsFifty of 104 patients (48%) exhibited NSLN metastasis. Univariate and multivariate analyses revealed that tumor size and the ratio of positive SLNs were significant risk factors of NSLN metastasis in patients with a positive SLN. The rate of NSLN metastasis was higher in patients with luminal/HER2+ and HER2 overexpression subtypes than that in patients with other subtypes in the univariate analysis (p<0.001). In the multivariate analysis, both patients with luminal/HER2+ (p<0.006) and patients with HER2 overexpression (p<0.031) subtypes had a higher risk of NSLN metastasis than patients with the luminal A subtype.
conclusionSubtype classification should be considered as an independent factor when evaluating the risk of NSLN metastasis in patients with a positive SLN. This result supports the development of new nomograms including breast cancer subtype to increase predictive accuracy.
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