ReviewInfection and drug resistance2014
Antibiotic lock therapy: review of technique and logistical challenges.
Review in Infection and drug resistance, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05971537 (Clinical Trial on Antibiotic-Lock in Tenckhoff Catheter for Relasping and Repeat Peritonitis), which is not on this map. Cited by 47 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Trial on Antibiotic-Lock in Tenckhoff Catheter for Relasping and Repeat Peritonitis
Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A comprehensive review of infection risks and management in hemodialysis access sites.Clinical and experimental nephrology · 2026Pooled it
- Interventions for treating catheter-related bloodstream infections in people receiving maintenance haemodialysis.The Cochrane database of systematic reviews · 2022Pooled it
- Tetrasodium EDTA central venous catheter lock solution in home parenteral nutrition patients: Ease of use and patient satisfaction, a prospective study.The journal of vascular access · 2026Article
- Timing of Antimicrobial Lock Replacement for Gram-Positive Port Infections: Results of a Randomized Trial.Antibiotics (Basel, Switzerland) · 2026Article
- Nitric Oxide-Releasing Thixotropic Hydrogels as Antibacterial and Hemocompatible Catheter Locks.ACS biomaterials science & engineering · 2026Article
- Article
- Analysis of the reasons for removal of vascular ports in patients treated in chemotherapy and gynecological oncology departments - preliminary investigations.Przeglad menopauzalny = Menopause review · 2025Article
- Efficacy of heparin-vancomycin-amikacin combination lock in preventing catheter-related infections in haemodialysis patients: a double-blind randomized clinical trial.Infection prevention in practice · 2025Article
- Antimicrobial Lock Therapy: A Strategy for Managing Catheter-Related Bacteremia.Antibiotics (Basel, Switzerland) · 2025Article
- Antibiotic lock therapy for the treatment of peripherally inserted central venous catheter-related bloodstream infection in patients with hematological malignancies: a single center retrospective study.Annals of hematology · 2025Article
- Antimicrobial Lock Therapy in Clinical Practice: A Scoping Review.Microorganisms · 2025Review
- Antibiotic lock solutions as adjunct therapy for catheter-related blood stream infections in pediatric hemodialysis patients.Frontiers in pediatrics · 2024Review
- Antimicrobial efficacy of a nitric oxide-releasing ampicillin conjugate catheter lock solution on clinically-isolated antibiotic-resistant bacteria.Biomaterials science · 2023Article
- Usefulness of daptomycin lock therapy in children with catheter-related bacteremia after failed vancomycin lock therapy.Annals of clinical microbiology and antimicrobials · 2023Article
- Effectiveness of Antimicrobial Lock Therapy for the Treatment of Catheter-Related and Central-Line-Associated Bloodstream Infections in Children: A Single Center Retrospective Study.Antibiotics (Basel, Switzerland) · 2023Article
- Do biosurfactants as anti-biofilm agents have a future in industrial water systems?Frontiers in bioengineering and biotechnology · 2023Review
- Antifungal lock therapy: an eternal promise or an effective alternative therapeutic approach?Letters in applied microbiology · 2022Review
- Environmental, Microbiological, and Immunological Features of Bacterial Biofilms Associated with Implanted Medical Devices.Clinical microbiology reviews · 2022Review
- Nitric Oxide-Releasing Lock Solution for the Prevention of Catheter-Related Infection and Thrombosis.ACS applied bio materials · 2022Article
- Antifungal activity of Taurolidine against Mucorales: An in vitro study on clinical isolates.Current medical mycology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antibiotic lock therapy (ALT) for the prevention and treatment of catheter-related bloodstream infections is a simple strategy in theory, yet its real-world application may be delayed or avoided due to technical questions and/or logistical challenges. This review focuses on these latter aspects of ALT, including preparation information for a variety of antibiotic lock solutions (ie, aminoglycosides, beta-lactams, fluoroquinolones, folate antagonists, glycopeptides, glycylcyclines, lipopeptides, oxazolidinones, polymyxins, and tetracyclines) and common clinical issues surrounding ALT administration. Detailed data regarding concentrations, additives, stability/compatibility, and dwell times are summarized. Logistical challenges such as lock preparation procedures, use of additives (eg, heparin, citrate, or ethylenediaminetetraacetic acid), timing of initiation and therapy duration, optimal dwell time and catheter accessibility, and risks of ALT are also described. Development of local protocols is recommended in order to avoid these potential barriers and encourage utilization of ALT where appropriate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.