ArticleWorld journal of gastroenterology2014
Ultrasound hepatic/renal ratio and hepatic attenuation rate for quantifying liver fat content.
Article in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 55 citations in OpenAlex.
- Metabolic dysfunction-associated steatotic liver disease and increased risk of atrial fibrillation in the elderly: A longitudinal cohort study.International journal of cardiology. Heart & vasculature · 2025Article
- Challenges and needs in the management of non-alcoholic fatty liver disease from the perspective of gastroenterology and hepatology specialists: a qualitative study.BMC gastroenterology · 2025Article
- Evaluation of Hepatic/Renal and Splenic/Renal Echointensity Ratio Using Ultrasonography in Diabetic Nephropathy.Diagnostics (Basel, Switzerland) · 2023Article
- CX08005, a Protein Tyrosine Phosphatase 1B Inhibitor, Attenuated Hepatic Lipid Accumulation and Microcirculation Dysfunction Associated with Nonalcoholic Fatty Liver Disease.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Association between triglyceride-glucose index and nonalcoholic fatty liver disease in type 2 diabetes mellitus.BMC endocrine disorders · 2022Article
- The triglyceride glucose-body mass index: a non-invasive index that identifies non-alcoholic fatty liver disease in the general Japanese population.Journal of translational medicine · 2022Article
- Correlation between hepatorenal index and attenuation imaging for assessing hepatic steatosis.Australasian journal of ultrasound in medicine · 2022Article
- Conventional and artificial intelligence-based imaging for biomarker discovery in chronic liver disease.Hepatology international · 2022Review
- General Overview About the Current Management of Nonalcoholic Fatty Liver Disease.Clinical drug investigation · 2022Review
- Effects of Different Scan Projections on the Quantitative Ultrasound-Based Evaluation of Hepatic Steatosis.Healthcare (Basel, Switzerland) · 2022Article
- Triglyceride affects the association between estimated glomerular filtration rate and the onset of non-alcoholic fatty liver disease: A second analysis of a Chinese cohort study.Frontiers in medicine · 2022Article
- Relationship between Quantitative Sonographic Measurements and Serum Biochemical Parameters in Childhood Obesity.Pediatric gastroenterology, hepatology & nutrition · 2021Article
- Effects of Lipid Deposition on Viscoelastic Response in Human Hepatic Cell Line HepG2.Frontiers in physiology · 2021Article
- Comparison of Body Mass Index and Fat Indices in Predicting the Severity of Nonalcoholic Fatty Liver Disease Among Children Who Are Overweight and Obese.Frontiers in pediatrics · 2021Article
- Comparison of sonographic hepatorenal ratio and the degree of hepatic steatosis in magnetic resonance imaging-proton density fat fraction.Journal of ultrasonography · 2020Article
- Advances in ultrasound elastography for nonalcoholic fatty liver disease.Journal of medical ultrasonics (2001) · 2020Review
- Noninvasive evaluation of nonalcoholic fatty liver disease: Current evidence and practice.World journal of gastroenterology · 2019Review
- Nonalcoholic fatty liver with a hepatic arterial buffer response strongly associated with future metabolic disease.Hepatology communications · 2017Article
- [Techniques for quantification of liver fat in risk stratification of diabetics].Der Radiologe · 2015Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo establish and validate a simple quantitative assessment method for nonalcoholic fatty liver disease (NAFLD) based on a combination of the ultrasound hepatic/renal ratio and hepatic attenuation rate.
methodsA total of 170 subjects were enrolled in this study. All subjects were examined by ultrasound and (1)H-magnetic resonance spectroscopy ((1)H-MRS) on the same day. The ultrasound hepatic/renal echo-intensity ratio and ultrasound hepatic echo-intensity attenuation rate were obtained from ordinary ultrasound images using the MATLAB program.
resultsCorrelation analysis revealed that the ultrasound hepatic/renal ratio and hepatic echo-intensity attenuation rate were significantly correlated with (1)H-MRS liver fat content (ultrasound hepatic/renal ratio: r = 0.952, P = 0.000; hepatic echo-intensity attenuation r = 0.850, P = 0.000). The equation for predicting liver fat content by ultrasound (quantitative ultrasound model) is: liver fat content (%) = 61.519 × ultrasound hepatic/renal ratio + 167.701 × hepatic echo-intensity attenuation rate -26.736. Spearman correlation analysis revealed that the liver fat content ratio of the quantitative ultrasound model was positively correlated with serum alanine aminotransferase, aspartate aminotransferase, and triglyceride, but negatively correlated with high density lipoprotein cholesterol. Receiver operating characteristic curve analysis revealed that the optimal point for diagnosing fatty liver was 9.15% in the quantitative ultrasound model. Furthermore, in the quantitative ultrasound model, fatty liver diagnostic sensitivity and specificity were 94.7% and 100.0%, respectively, showing that the quantitative ultrasound model was better than conventional ultrasound methods or the combined ultrasound hepatic/renal ratio and hepatic echo-intensity attenuation rate. If the (1)H-MRS liver fat content had a value < 15%, the sensitivity and specificity of the ultrasound quantitative model would be 81.4% and 100%, which still shows that using the model is better than the other methods.
conclusionThe quantitative ultrasound model is a simple, low-cost, and sensitive tool that can accurately assess hepatic fat content in clinical practice. It provides an easy and effective parameter for the early diagnosis of mild hepatic steatosis and evaluation of the efficacy of NAFLD treatment.
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