ReviewWorld journal of gastroenterology2014
Probiotics for antibiotic-associated diarrhea: do we have a verdict?
Review in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 62 citations in OpenAlex.
- Bio-Functional Properties of Lactic Acid Bacteria in Functional Foods.Foods (Basel, Switzerland) · 2026Article
- Overview of the Efficacy of Using Probiotics for Neurosurgical and Potential Neurosurgical Patients.Microorganisms · 2024Review
- Effects ofNutrients · 2023Article
- Probiotics, their prophylactic and therapeutic applications in human health development: A review of the literature.Heliyon · 2022Review
- Survey of potentially inappropriate prescriptions for common cold symptoms in Japan: A cross-sectional study.PloS one · 2022Article
- Green Banana Flour Contributes to Gut Microbiota Recovery and Improves Colonic Barrier Integrity in Mice Following Antibiotic Perturbation.Frontiers in nutrition · 2022Article
- Comparison of antibiotic-associated diarrhea caused by cefoperazone/sulbactam or piperacillin/tazobactam in neurosurgery patients.The Journal of international medical research · 2021Article
- SARS-CoV-2 microbiome dysbiosis linked disorders and possible probiotics role.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2021Review
- Risk factors, incidence, and morbidity associated with antibiotic-associated diarrhea in intensive care unit patients receiving antibiotic monotherapy.World journal of clinical cases · 2020Article
- Probiotics and Clostridium Difficile: A Review of Dysbiosis and the Rehabilitation of Gut Microbiota.Cureus · 2019Review
- Clostridium difficile, the Difficult "Kloster" Fuelled by Antibiotics.Current microbiology · 2019Review
- Gut microbiome associated with chemotherapy-induced diarrhea from the CapeOX regimen as adjuvant chemotherapy in resected stage III colorectal cancer.Gut pathogens · 2019Article
- A double blind, placebo-controlled, randomized clinical trial that breast milk derived-Journal of clinical biochemistry and nutrition · 2018Article
- Probiotics in Children: What Is the Evidence?Pediatric gastroenterology, hepatology & nutrition · 2017Review
- Probiotics Ingestion Does Not Directly Affect Thyroid Hormonal Parameters in Hypothyroid Patients on Levothyroxine Treatment.Frontiers in endocrinology · 2017Article
- Recurrence of Clostridium difficile Infection in Patients with Inflammatory Bowel Disease: The RECIDIVISM Study.The American journal of gastroenterology · 2016Article
- Fecal microbiota transplantation for severe clostridium difficile infection after left ventricular assist device implantation: a case control study and concise review on the local and regional therapies.BMC infectious diseases · 2016Review
- Importance of Molecular Methods to Determine Whether a Probiotic is the Source of Lactobacillus Bacteremia.Probiotics and antimicrobial proteins · 2016Article
- Heat-killed Lactobacillus Reuteri GMNL-263 Prevents Epididymal Fat Accumulation and Cardiac Injury in High-Calorie Diet-Fed Rats.International journal of medical sciences · 2016Article
- Controversies Around Epidemiology, Diagnosis and Treatment of Clostridium difficile Infection.Drugs · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Probiotics use has increased tremendously over the past ten years. This was coupled with a surge of data relating their importance in clinical practice. Antibiotic-associated diarrhea, whose frequency has risen recently, was one of the earliest targets with data published more than ten years ago. Unfortunately, available trials suffer from severe discrepancies associated with variability and heterogeneity of several factors. Most published randomized controlled trials and subsequent meta-analyses suggest benefit for probiotics in the prevention of antibiotic-associated diarrhea. The same seems to also apply when the data is examined for Clostridium difficile-associated colitis. However, the largest randomized double-blind placebo-controlled trial to date examining the use of a certain preparation of probiotics in antibiotic-associated diarrhea showed disappointing results, but it was flawed with several drawbacks. The commonest species of probiotics studied across most trials is Lactobacillus; however, other types have also shown similar benefit. Probiotics have enjoyed an impeccable safety reputation. Despite a few reports of severe infections sometimes leading to septicemia, most of the available trials confirm their harmless behavior and show similar adverse events compared to placebo. Since a consensus dictating its use is still lacking, it would be advisable at this point to suggest prophylactic use of probiotics to certain patients at risk for antibiotic-associated diarrhea or to those who suffered previous episodes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.