ArticleIndian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion2015
Clinicoinvestigational and demographic profile of children with thalassemia major.
Article in Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Clinico-epidemiological Profile of Transfusion-dependent Thalassemia Patients in a Tertiary Care Children's Hospital in Nepal: An Observational Study.JNMA; journal of the Nepal Medical Association · 2025Observational
- Nursing interventions for improving quality of life among parents with major Thalassemic children: a scoping review.BMC nursing · 2025Article
- Psychiatric disorders and caregiver burden in children with transfusion dependent β-thalassaemia and their caregivers.World journal of clinical pediatrics · 2023Article
- High Serum Ferritin Levels among Blood Transfused Thalassemic Patients Admitted to the Department of Paediatrics in a Tertiary Care Centre: A Descriptive Cross-Sectional Study.JNMA; journal of the Nepal Medical Association · 2023Article
- Significance of genetic modifiers of hemoglobinopathies leading towards precision medicine.Scientific reports · 2021Article
- Malnutrition, Its Attributes, and Impact on Quality of Life: An Epidemiological Study among β-Thalassemia Major Children.Korean journal of family medicine · 2021Article
- Time to Start Delivering Iron Chelation Therapy in Newly Diagnosed SevereBioMed research international · 2020Article
- Haemoglobinopathies in India: estimates of blood requirements and treatment costs for the decade 2017-2026.Journal of community genetics · 2020Article
- Association of frequency of hereditary hemochromatosis (HFE) gene mutations (H63D and C282Y) with iron overload in beta-thalassemia major patients in Pakistan.Saudi medical journal · 2019Article
- Socio-demographic Profile and Economic Burden of Treatment of Transfusion Dependent Thalassemia.Indian journal of pediatrics · 2018Article
- Thalassemia, extramedullary hematopoiesis, and spinal cord compression: A case report.Surgical neurology international · 2016Article
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5 authors.
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Abstract
There are an estimated 200 million carriers of the β-thalassemia gene worldwide, 20 million being in India. The mean prevalence in India is 3.3 %. Objective To evaluate the clinico-investigational profile and the demographic characteristics of patients with thalassemia major (TM). Methods This was a retrospective analysis of the clinico-demographic profile at presentation of patients of TM diagnosed in the Paediatric Hematology Clinic of our hospital. Results The clinical profile of 964 patients of TM was analyzed. The mean age at presentation of untransfused children was 13.2 ± 9.7 months. Nearly 2/3(rd) children presented before 1 year of age. Almost 40 % had symptoms for 3 months prior to presentation. The manifestations at presentation included pallor and failure to thrive. About 40 % presented with severe anemia, with a hemoglobin of <5.0 gm/dl. A large number received blood transfusions prior to establishment of the diagnosis. Half of the families had ancestors who hailed originally from Pakistan. Approximately 50 % belonged to the Khatri/Arora castes. The parental literacy rate was about 90 %. Conclusions Thalassemia needs greater public awareness and prevention strategies in our country. Some communities are at high risk as compared to others. Education programs and compulsory antenatal screening appear to be the order of the day.
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