Evidence map›Paper›PMID 25548437›Full record

ArticleIndian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion2015

Improving Outcome of Aplastic Anaemia with HLA-Matched Sibling Donor Hematopoietic Stem Cell Transplantation: An Experience of Gujarat Cancer and Research Institute (GCRI).

Shreeniwas S Raut, Sandip A Shah, Kinnari A Patel, Kamlesh M Shah, Asha S Anand, Shailesh S Talati, Harsha P Panchal, Apurva A Patel, Sonia K Parikh, Bhavesh B Parekh and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Comparing Outcomes with Bone Marrow or Peripheral Blood Stem Cells as Graft Source for Matched Sibling Transplants in Severe Aplastic Anemia across Different Economic Regions.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2016
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Shreeniwas S RautCivil Hospital, GCRI, Room No. 35, P.G. Hostel, GCRI Campus, Ahmedabad, 380016 Gujarat India.
Sandip A ShahCivil Hospital, GCRI, Room No. 35, P.G. Hostel, GCRI Campus, Ahmedabad, 380016 Gujarat India.
Kinnari A PatelCivil Hospital, GCRI, Room No. 35, P.G. Hostel, GCRI Campus, Ahmedabad, 380016 Gujarat India.
Kamlesh M ShahCivil Hospital, GCRI, Room No. 35, P.G. Hostel, GCRI Campus, Ahmedabad, 380016 Gujarat India.
Asha S AnandCivil Hospital, GCRI, Room No. 35, P.G. Hostel, GCRI Campus, Ahmedabad, 380016 Gujarat India.
Shailesh S TalatiCivil Hospital, GCRI, Room No. 35, P.G. Hostel, GCRI Campus, Ahmedabad, 380016 Gujarat India.
Harsha P PanchalCivil Hospital, GCRI, Room No. 35, P.G. Hostel, GCRI Campus, Ahmedabad, 380016 Gujarat India.
Apurva A PatelCivil Hospital, GCRI, Room No. 35, P.G. Hostel, GCRI Campus, Ahmedabad, 380016 Gujarat India.
Sonia K ParikhCivil Hospital, GCRI, Room No. 35, P.G. Hostel, GCRI Campus, Ahmedabad, 380016 Gujarat India.
Bhavesh B ParekhCivil Hospital, GCRI, Room No. 35, P.G. Hostel, GCRI Campus, Ahmedabad, 380016 Gujarat India.
Shilin N ShuklaCivil Hospital, GCRI, Room No. 35, P.G. Hostel, GCRI Campus, Ahmedabad, 380016 Gujarat India.
Gujarat Cancer & Research Institute · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fifteen patients, with a median age of 19 years having severe aplastic anaemia (SAA) underwent human leucocyte antigen (HLA) identical sibling donor hematopoietic stem cell transplantation (HSCT) using conditioning regimens containing cyclophosphamide with antithymocyte globulin (ATG) or a combination of fludarabine and cyclophosphamide with or without ATG during December 2007 to May 2013. Cyclosporine and mini methotrexate were used as graft versus host disease (GVHD) prophylaxis. Graft source included peripheral blood stem cells in 11, bone marrow in 3 and both in 1. One patient had primary graft failure while 14 patients were engrafted with a median neutrophil and platelet engraftment time of 13.5 days. One patient had secondary graft rejection. Acute GVHD occurred in 3 patients and chronic GVHD in 4. One year death rate in engrafted patients was 14.28 %. At a mean follow-up of 21.2 months, 12 (80 %) are alive and well. One of the donors was a patient of haemophilia but the disease did not occur in the recipient. The graft was successful and the recipient is alive till date.

Indexed as

Allogeneic bone marrow transplantationAplastic anaemiaGujaratHLA-matched sibling-donorPeripheral blood stem cell transplantation

Identifiers

PMID25548437
PMCPMC4275516
OpenAlexW2056258689

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.