ArticleMediators of inflammation2014
Elevated serum IgG4 defines specific clinical phenotype of rheumatoid arthritis.
Article in Mediators of inflammation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 42 citations in OpenAlex.
- Differential associations of IgG-aFcεRI and IgG-aIgE autoantibodies with clinical phenotypes of type IIb chronic spontaneous urticaria.The World Allergy Organization journal · 2026Article
- [Rheumatoid arthritis combined with IgG4-related disease successfully treated with rituximab: A case report].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2025Article
- IMGTNAR genomics and bioinformatics · 2025Article
- Review
- Comparison of IgG4 with inflammatory cytokines (IL-1, IL-6 and TNFα) in rheumatoid arthritis.Frontiers in immunology · 2025Article
- IgG4-related disease: an update on pathology and diagnostic criteria with a focus on salivary gland manifestations.Virchows Archiv : an international journal of pathology · 2024Review
- IgG4 serologic elevation in a patient with severe hidradenitis suppurativa: a case report and review of the literature.Frontiers in medicine · 2024Article
- A retrospective multicenter study on clinical and serological parameters in patients with MuSK myasthenia gravis with and without general immunosuppression.Frontiers in immunology · 2024Article
- Serum immunoglobulin and the threshold of Fc receptor-mediated immune activation.Biochimica et biophysica acta. General subjects · 2023Review
- Immunoglobulin G4-Related Lesions in Autoimmune Diseases: Unusual Presentations at Atypical Sites-A Tale of 2 Cases with Literature Review.European journal of rheumatology · 2023Article
- Decoding the Clinical Significance of Immunoglobulin G4 in Rheumatoid Arthritis.Journal of clinical medicine · 2023Article
- The role of Th17 cells: explanation of relationship between periodontitis and COPD?Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022Review
- Frequency and Clinical Significance of Elevated IgG4 in Rheumatoid Arthritis: A Systematic Review.Biomedicines · 2022Review
- Unique Challenges in Diagnosing IgG4-Related Tubulointerstitial Nephritis with Arteritis.Kansas journal of medicine · 2022Article
- Lyme arthritis: linking infection, inflammation and autoimmunity.Nature reviews. Rheumatology · 2021Review
- TDP-43-specific Autoantibody Decline in Patients With Amyotrophic Lateral Sclerosis.Neurology(R) neuroimmunology & neuroinflammation · 2021Article
- IgG4-related disease: a great mimicker of lung cancer.BMJ case reports · 2021Article
- The Role of IgG4 in Autoimmunity and Rheumatic Diseases.Frontiers in immunology · 2021Review
- Mitral valvulitis as a severe extra-articular manifestation of rheumatoid arthritis: a case report.European heart journal. Case reports · 2021Article
- Increased Circulating CD4Journal of immunology research · 2021Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo explore the correlation of serum IgG4 (sIgG4) with clinical manifestations or therapeutic response in rheumatoid arthritis (RA).
methodsConsecutive 136 RA patients were recruited and followed up at regular interval. SIgG4 was detected by immunonephelometry. Serial synovial tissue sections from 46 RA patients were stained immunohistochemically for IgG4.
resultsForty-six percent of 136 RA patients had elevated sIgG4. Patients with elevated sIgG4 had higher sIgG4/sIgG ratio, C-reactive protein, erythrocyte sedimentation rate, rheumatoid factor, and anticyclic citrullinated peptide antibodies than those with normal sIgG4 (all P < 0.05). Among 45 patients who received methotrexate and leflunomide therapy, 50% (9/18) of patients with elevated sIgG4 and 85% (23/27) of patients with normal sIgG4 reached therapeutic target (disease activity score of 28 joints < 3.2) at 6-month visit (χ(2) = 6.508, P = 0.011). IgG4-positive plasma cell count correlated positively with sIgG4, total synovitis score, and CD3-, CD20-, and CD38-positive cell counts (all P < 0.05).
conclusionsOur results showed that elevated sIgG4 in RA is common and disproportional to total IgG and RA with elevated sIgG4 may be a specific clinical phenotype with higher disease activity, higher level of autoantibodies, and poor response to methotrexate and leflunomide therapy.
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