ArticleThe Korean journal of parasitology2014
Scolicidal effects of black cumin seed (Nigella sativa) essential oil on hydatid cysts.
Article in The Korean journal of parasitology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Pooled it
- Effect of aminomix-1 solution as an in vitro scolicidal agent on the bile ducts and liver in rats: a controlled experimental animal study.Sao Paulo medical journal = Revista paulista de medicina · 2026Article
- In vitro evaluation of the susceptibility of Echinococcus granulosus hydatid cysts to lavender and green tea extracts.Scientific reports · 2025Article
- Efficacy and mechanism of action of harmine derivative H-2-104 against Echinococcus granulosus infection in mice.BMC veterinary research · 2025Article
- Epidemiological study on bovine cystic echinococcosis: Abattoir survey, cyst characterization and its economic impact at Mekaneyesuse municipality abattoir, Northwest Ethiopia.Parasite epidemiology and control · 2024Article
- Anthelmintic Effect of Cannabidiol againstTropical medicine and infectious disease · 2024Article
- Eugenol Essential Oil and Nanoemulsion as Antihydatic Agents with Antifibrotic and Immunomodulatory Effects in Cystic Echinococcosis.Tropical medicine and infectious disease · 2023Article
- An Inventory of Anthelmintic Plants across the Globe.Pathogens (Basel, Switzerland) · 2023Review
- Essential Oils as Novel Anthelmintic Drug Candidates.Molecules (Basel, Switzerland) · 2022Review
- A systematic appraisal of the use of carvacrol-rich plants to treat hydatid cysts.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022Review
- Herbal Medicines against Hydatid Disease: A Systematic Review (2000-2021).Life (Basel, Switzerland) · 2022Review
- Evaluation of the scolicidal activities of eugenol essential oil and its nanoemulsion against protoscoleces of hydatid cysts.PloS one · 2021Article
- Effect of Taxus baccata L. Extract on Hydatid Cyst Protoscolices In vitro.Archives of Razi Institute · 2021Article
- Echinococcosis: Advances in the 21st Century.Clinical microbiology reviews · 2019Review
- Progress in the pharmacological treatment of human cystic and alveolar echinococcosis: Compounds and therapeutic targets.PLoS neglected tropical diseases · 2018Article
- Article
- Scolicidal agents for protoscolices ofJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2017Review
- Article
- Effect of Nigella sativa oil on experimental toxoplasmosis.Parasitology research · 2016Article
- Phytochemical compositions and biological activities of essential oil from Xanthium strumarium L.Molecules (Basel, Switzerland) · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Surgery remains the preferred treatment for hydatid cyst (cystic echinococcosis, CE). Various scolicidal agents have been used for inactivation of protoscolices during surgery, but most of them are associated with adverse side effects. The present study aimed to evaluate the in vitro scolicidal effect of Nigella sativa (Ranunculaceae) essential oil and also its active principle, thymoquinone, against protoscolices of hydatid cysts. Protoscolices were aseptically aspirated from sheep livers having hydatid cysts. Various concentrations of the essential oil (0.01-10 mg/ml) and thymoquinone (0.125-1.0 mg/ml) were used for 5 to 60 min. Viability of protoscolices was confirmed by 0.1% eosin staining. Furthermore, the components of the N. sativa essential oil were identified by gas chromatography/mass spectroscopy (GC/MS). Our study revealed that the essential oil of N. sativa at the concentration of 10 mg/ml and its main component, thymoquinone, at the concentration of 1 mg/ml had potent scolicidal activities against protoscolices of Echinococcus granulosus after 10 min exposure. Moreover, thymoquinone (42.4%), p-cymene (14.1%), carvacrol (10.3%), and longifolene (6.1%) were found to be the major components of N. sativa essential oil by GC/MS analysis. The results of this study indicated the potential of N. sativa as a natural source for production of a new scolicidal agent for use in hydatid cyst surgery. However, further studies will be needed to confirm these results by checking the essential oil and its active component in in vivo models.
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Registered trials
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