ArticleThe Canadian journal of hospital pharmacy2014
Achieving therapeutic vancomycin levels in pediatric patients.
Article in The Canadian journal of hospital pharmacy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02694458 (Comparison of Two Dosage Adjustment Strategies of Vancomycin in Children), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of Two Dosage Adjustment Strategies of Vancomycin in Children
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Determining the optimal vancomycin daily dose for pediatrics: a meta-analysis.European journal of clinical pharmacology · 2017Pooled it
- Prediction of Vancomycin Area Under the Curve With Trough Concentrations Only: Performance Evaluation of Pediatric Population Pharmacokinetic Models.The Journal of infectious diseases · 2025Article
- Integrated Electrochemical Aptamer Biosensing and Colorimetric pH Monitoring via Hydrogel Microneedle Assays for Assessing Antibiotic Treatment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- An evaluation of the empirical vancomycin dosing guide in pediatric cardiology.BMC pediatrics · 2024Article
- Practical approaches to improve vancomycin-related patient outcomes in pediatrics- an alternative strategy when AUC/MIC is not feasible.BMC pharmacology & toxicology · 2022Article
- Assessment of initial vancomycin trough levels and risk factors of vancomycin-induced nephrotoxicity in neonates.European journal of hospital pharmacy : science and practice · 2022Article
- Population Pharmacokinetics and Dose Optimization of Vancomycin in Critically Ill Children.European journal of drug metabolism and pharmacokinetics · 2021Article
- Vancomycin Prescribing Practices and Therapeutic Drug Monitoring for Critically Ill Neonatal and Pediatric Patients: A Survey of Physicians and Pharmacists in Hong Kong.Frontiers in pediatrics · 2020Article
- Effect of Vancomycin Loading Doses on the Attainment of Target Trough Concentrations in Hospitalized Children.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2020Article
- Evaluation of vancomycin initial trough levels in children: A 1-year retrospective study.SAGE open medicine · 2020Article
- Treatment of Methicillin-Resistant Staphylococcus aureus (MRSA) Infections in Children: a Reappraisal of Vancomycin.Current infectious disease reports · 2019Review
- Describing vancomycin serum levels in pediatric intensive care unit (ICU) patients: are expected goals being met.BMC pediatrics · 2019Article
- A population pharmacokinetic model for individualised dosage regimens of vancomycin in Chinese neonates and young infants.Oncotarget · 2017Article
- Zunyimycins B and C, New Chloroanthrabenzoxocinones Antibiotics against Methicillin-Resistant Staphylococcus aureus and Enterococci from Streptomyces sp. FJS31-2.Molecules (Basel, Switzerland) · 2017Article
- Risk Factors for Non-Therapeutic Initial Steady-State Vancomycin Trough Concentrations in Children and Adolescents Receiving High Empiric Doses of Intravenous Vancomycin.Paediatric drugs · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVancomycin is widely used to treat infections caused by methicillin-resistant Staphylococcus aureus. Data for dosing and monitoring of this drug in pediatric patients are lacking, and clinicians who are treating children often follow guidelines established for adults.
objectivesTo examine the total daily doses of vancomycin required to reach therapeutic trough levels (i.e., 10-20 mg/L) in infants, children, and adolescents, and to assess the number of pediatric patients in whom therapeutic trough levels are achieved with current empiric doses (40-60 mg/kg daily).
methodsThis chart review evaluated patients 1 month to 18 years of age for whom vancomycin was prescribed at a single institution between November 2011 and October 2012. Patients' demographic characteristics, vancomycin dosing parameters, and subsequent steady-state trough concentrations were analyzed.
resultsOverall, the proportion of patients who reached therapeutic trough levels with current empiric doses was 39% (74 of 188). The mean total daily dose (± standard deviation) required to achieve therapeutic trough levels was 57.8 ± 11.5 mg/kg for patients 1 to 5 months of age, 68.9 ± 15.4 mg/kg for those 6 to 23 months of age, 65.8 ± 13.0 mg/kg for those 2 to 12 years of age, and 55.7 ± 11.8 mg/kg for those 13 to 18 years of age.
conclusionsCommon empiric vancomycin dosing regimens (40-60 mg/kg daily) are not high enough to achieve trough levels of 10-20 mg/L in the majority of pediatric patients. Given these data, the authors suggest a starting dose of 60 mg/kg daily for patients 1 to 5 months of age and those 13 to 18 years of age and a starting dose of 70 mg/kg daily for patients 6 months to 12 years of age.
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