Evidence map›Paper›PMID 25548393›Full record

ArticleBiological research for nursing2015

Plasma Estrogen Levels Are Associated With Severity of Injury and Outcomes After Aneurysmal Subarachnoid Hemorrhage.

Elizabeth A Crago, Paula R Sherwood, Catherine Bender, Jeffrey Balzer, Dianxu Ren, Samuel M Poloyac

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological research for nursing, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Elizabeth A CragoSchool of Nursing, University of Pittsburgh, Pittsburgh, PA, USA ecrago@pitt.edu.
Paula R SherwoodSchool of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.
Catherine BenderSchool of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.
Jeffrey BalzerSchool of Nursing, University of Pittsburgh, Pittsburgh, PA, USA Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Dianxu RenSchool of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.
Samuel M PoloyacSchool of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, USA.
University of Pittsburgh · USNeurological Surgery · US

Funding

Role of 20-HETE on Vasospasm-Induced Ischemia after Subarachnoid HemorrhageR01NR004339 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI POLOYAC, SAMUEL M, SHERWOOD, PAULA R · 1999 to 2013
$7.2M
Myocardial Ischemia and Vasospasm in Aneurysmal SAHR01HL074316 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HOROWITZ, MICHAEL B · 2004 to 2008
$2.8M
NCATS NIH HHS L30 TR001223NHLBI NIH HHS R01 HL074316NINR NIH HHS R01 NR004339
6 · The paper itself

Abstract

backgroundBiochemical mediators alter cerebral perfusion and have been implicated in delayed cerebral ischemia (DCI) and poor outcomes after aneurysmal subarachnoid hemorrhage (aSAH). Estrogens (estrone [E1] and estradiol [E2]) are mediators with neuroprotective properties that could play a role in DCI. This study explored associations between plasma estrogen levels and outcomes following aSAH.

methodsPlasma samples from 1-4, 4-6, and 7-10 days after hemorrhage from 99 adult aSAH patients were analyzed for estrogen levels using liquid chromatography tandem mass spectrometry. DCI was operationalized as radiographic/ultrasonic evidence of impaired cerebral blood flow accompanied by neurological deterioration. Outcomes were assessed using the Modified Rankin Scale at 3 and 12 months after hemorrhage. Statistical analysis included correlation, regression, and group-based trajectory.

resultsHigher E1 and E2 levels were associated with higher Hunt and Hess grade (E1, p = .01; E2, p = .03), the presence of DCI (E1, p = .02; E2, p = .02), and poor 3-month outcomes (E1, p = .002; E2, p = .002). Trajectory analysis identified distinct populations over time for E1 (61% E1 high) and E2 (68% E2 high). Patients in higher trajectory groups had higher Fisher grades (E1, p = .008; E2, p = .01), more frequent DCI (E1, p = .04; E2, p = .08), and worse 3-month outcomes (E1, p = .01; E2, p = .004) than low groups.

conclusionsThese results provide the first clinical evidence that plasma E1 and E2 concentrations are associated with severity of injury and outcomes after aSAH.

Indexed as

Trauma Severity IndicesAdultAgedBiomarkersCerebrovascular CirculationEstradiolEstroneFemaleHumansMaleMass SpectrometryMiddle AgedSubarachnoid HemorrhageBiomarkersEstradiolEstronedelayed cerebral ischemiaestrogenoutcomessubarachnoid hemorrhage

Identifiers

PMID25548393
PMCPMC4545417
OpenAlexW2147577487

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.