ArticlePhilosophical transactions. Series A, Mathematical, physical, and engineering sciences2015
High-resolution joint symbolic analysis to enhance classification of the cardiorespiratory system in patients with schizophrenia and their relatives.
Article in Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- Characterization of cardiac autonomic dysfunction in acute Schizophrenia: a cluster analysis of heart rate variability parameters.Schizophrenia (Heidelberg, Germany) · 2025Article
- A new directionality index based on high-resolution joint symbolic dynamics to assess information transfer in multivariate networks.Frontiers in neuroscience · 2025Article
- The Cardiorespiratory Network in Healthy First-Degree Relatives of Schizophrenic Patients.Frontiers in neuroscience · 2020Article
- Risk Stratification in Idiopathic Dilated Cardiomyopathy Patients Using Cardiovascular Coupling Analysis.Frontiers in physiology · 2019Article
- Baroreflex Coupling Assessed by Cross-Compression Entropy.Frontiers in physiology · 2017Article
- Cardiovascular coupling during graded postural challenge: comparison between linear tools and joint symbolic analysis.Brazilian journal of physical therapy · 2016Article
- Central- and autonomic nervous system coupling in schizophrenia.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2016Article
- Enhancing dynamical signatures of complex systems through symbolic computation.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2015Article
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Authors and funding
4 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Schizophrenia as a mental illness is one of the most serious in the world. Patients with schizophrenia have an increased cardiac mortality rate, but the reasons for this remain unclear. In addition to other factors, the role of impaired autonomic regulation during acute psychosis has become more evident in different studies applying heart rate (HR) variability analyses. But, until now, respiration and cardiorespiratory regulation, which are important for homeostatic control, have not been considered. In this study, short-term cardiorespiratory couplings (CRCs) of 23 unmedicated patients with paranoid schizophrenia (SZO), 20 of their healthy first-degree relatives (REL) and 20 healthy subjects (CON) matched according to age and sex of SZO and REL were investigated by applying high-resolution joint symbolic dynamics (HRJSD) analysis. We found a significantly (p<0.0061) altered HR pattern, respiratory pattern and CRCs in SZO and only marginal alterations for the REL group in comparison with the CON group when we applied HRJSD. These results might be an indication of decreased vagal activity within the brainstem, an altered or suppressed interaction of the brainstem and higher regulatory centres, or panic- and anxiety-related changes in the brainstem associated with the acute psychosis of these patients.
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